Journal Article

Hepatic glycogen storage diseases are associated to microbial dysbiosis

Bento dos Santos, Bruna, Moura de Souza, Carolina Fischinger, Dobbler, Priscila Thiago, Roesch, Luiz Fernando Wurdig, Schwartz, Ida Vanessa Doederlein, Colonetti, Karina, Nalin, Tatiéle, Triplett, Eric W.

2019

Overview

The gut microbiome has been related to several features present in Glycogen Storage Diseases (GSD) patients including obesity, inflammatory bowel disease (IBD) and liver disease. The primary objective of this study was to investigate associations between GSD and the gut microbiota. Twenty-four GSD patients on treatment with uncooked cornstarch (UCCS), and 16 healthy controls had their faecal microbiota evaluated through 16S rRNA gene sequencing. Patients and controls were [greater than or equal to]3 years of age and not on antibiotics. Faecal pH, calprotectin, mean daily nutrient intake and current medications were recorded and correlated with gut microbiome. GSD patients presented intestinal dysbiosis, showing low faecal microbial diversity in comparison with healthy controls. Those findings might be due to the disease per se, and/or to the different diets, use of UCSS and of medicines, and obesity rate found in patients. Although the main driver of these differences is unknown, this study might help to understand how the nutritional management affects GSD patients.

• Publisher: Public Library of Science
• Subject: Angiotensins / Antibiotics / Care and treatment / Coastal surveillance / Complications and side effects / Dysbiosis / Enzyme inhibitors / Enzymes / Gastrointestinal diseases / Genes / Glycogen / Glycogen storage diseases / Liver diseases / Medical research / Microbiota (Symbiotic organisms) / Multivitamins / Obesity / Polysaccharides / Risk factors / RNA / Sugar