Asset Details
Do you wish to reserve the book?
Mitochondrial fission requires DRP1 but not dynamins
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mitochondrial fission requires DRP1 but not dynamins
Do you wish to request the book?
Mitochondrial fission requires DRP1 but not dynamins
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mitochondrial fission requires DRP1 but not dynamins
2019
Overview
[...]DRP1 silencing resulted in an approximately 50% decrease in the number of individual mitochondria per ROI, both in wild-type and dynamin triple-knockout cells (Fig. 1l). The kinetics of mitochondrial fission were also indistinguishable between scrambled control and DNM2-knockdown HeLa cells (Extended Data Fig. 1u; Supplementary Video 2). [...]the steady-state level of mitochondrial fission or fusion is unaltered in dynamin triple-knockout and DNM2-knockdown cells, under basal culture conditions. [...]our results show that dynamin proteins are not required for mitochondrial fission, under both basal and stimulated conditions. [...]the selection of cellular models is probably not an explanation for why our data are in contrast with the earlier report that used HeLa and Cos7 cells with knockdown of DNM2 as experimental model5.
