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Optimization of PVA Concentration in the Preparation of Amlodipine Besylate Microparticles with Ethyl Cellulose Polymer Based on Entrapment Efficiency
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Optimization of PVA Concentration in the Preparation of Amlodipine Besylate Microparticles with Ethyl Cellulose Polymer Based on Entrapment Efficiency
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Optimization of PVA Concentration in the Preparation of Amlodipine Besylate Microparticles with Ethyl Cellulose Polymer Based on Entrapment Efficiency
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Journal Article
Optimization of PVA Concentration in the Preparation of Amlodipine Besylate Microparticles with Ethyl Cellulose Polymer Based on Entrapment Efficiency
2023
Overview
Amlodipine besylate, which is degraded at acidic pH, makes amlodipine besylate less suitable for targeting the stomach. [...]it is more suitable for targeted delivery systems to the intestine. Because it includes a large number of hydroxyl groups that can form hydrogen bonds, PVA is employed as a stabilizer. Amlodipine besylate - ethyl cellulose solution was mixed by dripping slowly into various concentrations of PVA solution, then stirred at 500 rpm for 120 minutes at room temperature. Microparticulate drug delivery systems have recently attracted a lot of attention in comparison to single unit systems because of their prospective benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation, and predictable gastric emptying [8].
Publisher
Journal of Pharmaceutical Sciences and Research
Subject
