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59 Which pesticides should be monitored in Latvian citizens? hanlon method adaptation for chemical prioritization in HBM4LV study
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Journal Article
59 Which pesticides should be monitored in Latvian citizens? hanlon method adaptation for chemical prioritization in HBM4LV study
2025
Overview
ObjectiveHuman biomonitoring is a tool used for the assessment of total exposure to chemicals. This approach considers exposure from any pathway and measures the detection or concentration of pesticides directly in human samples, mainly urine. It is not feasible to measure all chemicals in the human body; therefore, a prioritization strategy is crucial to determine which chemicals will be measured and evaluated in the study.Materials and MethodsIn the HBM4LV project, an adaptation of the Hanlon method is used to score and categorize pesticides. Information on problem size (max 60 points), characteristics of hazardousness (max 30 points), exposure (max 30 points), national importance (max 15 points), and societal concern (max 15 points) are the components of the adapted Hanlon equation. Additionally, weights are applied. The substances are then ranked and discussed with experts from the Human Biomonitoring Council to reach a consensus on the chemicals that should be monitored in Latvian citizens.ResultsSeven pesticides have been evaluated so far. Previous research focused on Latvian citizens' exposure to halogen-containing pesticides suggests that Acetamiprid, Chlorpropham, Boscalid, and Triclosan were detected in at least 15% of all samples. Additionally, the three most distributed pesticides are Glyphosate, Chlormequat chloride, and MCPA, so they were evaluated as well. After evaluation, Glyphosate (129.3 points), Acetamiprid (103.5 points), and MCPA (79.8 points) are of the highest priority for inclusion in the Latvian human biomonitoring program.ConclusionsOur approach suggests a modified Hanlon method that takes into account national importance and thus could be used by other countries for a chemical prioritization strategy of a nationwide study/program.AcknowledgementsThis study is funded by the State Research Program ‘Development of Human Biomonitoring Program for Latvia - HBM4LV’, project nr. VPP-VM-Sabiedrības_Veselība-2023/4- 0001.
Publisher
BMJ Publishing Group LTD
Subject
/ Exposure
