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Adenovirus keratitis challenge
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Trade Publication Article
Adenovirus keratitis challenge
2019
Overview
Researchers target form of conjunctivitis MUCH HAS BEEN learned about epidemic keratoconjunctivitis (EKC) since it was first described in 1889, yet aspects of the viral pathogenesis of adenovirus keratitis have remained an enigma, according to James Chodosh, MD, MPH, the David Glendenning Cogan Professor of Ophthalmology in the field of cornea and external disease, Massachusetts Eye and Ear, Harvard Medical School. Dr. Chodosh referred to the work of the late Prof. Barrie Jones of Moorfields Eye Hospital, who postulated that the adenovirus grows in the epithelial cells alone, and in killing them, liberates antigens, which soak into the underlying stroma to become fixed in the surface of fiber and cell membranes. PATHOGENESIS MODEL He described a proposed pathogenesis model for adenoviral keratitis: * Infection of the ocular surface epithelium * Interaction between the viral capsid and molecular pattern receptors on corneal cells * Intracellular signaling * Chemokine expression * Binding of chemokine protein to epithelial basement membrane * Migration of limbal leukocytes to chemokine reservoirs at corneal epithelial basement membrane, forming infiltrates within corneal subepithelial stroma Based on this model, Dr. Chodosh would rewrite Jones' statement to say: \"I postulate that the virus grows on the surface, initiating the expression of chemo-attractants which soak into the stroma to become fixed in the underlying basement membrane.
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