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"Anderson, Matthew"
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تاريخ القرن الثامن عشر في أوروبة
يبحث في تاريخ القرن الثامن عشر في أوربا من خلال المصادر والوثائق والمذكرات والقصص والبينات الاجتماعية والحياة الاقتصادية والحكومة والإدارة والملوك والمستدين والتوتر في داخل الدول والجيوش البرية والبحرية والدبلوماسية والعلاقات والدولية، وتوسع روسيا، ويتحدث عن الدول الألمانية وصعود بروسيا، ويدرس إسبانيا وإيطاليا والبحر المتوسط والتنافس الاستعمار وأوربا والعالم والخارجي والتعليم والحياة والفكرية والدين والكنائس.
BOOK
Prophets of Love
Leonard Cohen and the Apostle Paul might be imagined as brothers with wildly different characters but a strong family resemblance. Paul, the elder sibling, was awkward, abrasive, and zealous. Leonard, the successful younger brother, was a smooth-talking romantic, prone to addiction and depression. Paul died a martyr, not knowing his words would have any effect on the world. Leonard could see his canonization within his lifetime. Yet each became a prophet in his own time, and a poet for the ages.
In Prophets of Love Matthew Anderson traces surprising connections between two Jewish thinkers separated by millennia. He explores Leonard's and Paul's mysticism, their Judaism, their fascination with Jesus, their countercultural perspectives on sex, their ideas about love, and how they each embodied being men. Anderson considers their ambiguous relationships with women, on whom they depended and from whom they often profited, as well as how their legacies continue to evolve and be re-interpreted. This book emphasizes that Paul was first and foremost a Jew, and never rejected his Judaism. At the same time, it sheds new light on the biblical worldviews and language underlying and inspiring every line of Cohen's poetry.
Prophets of Love alters our views of both Leonard Cohen and the Apostle Paul, re-introducing us to two poetic prophets of divine and human love.
eBook
A framework for enhancing ethical genomic research with Indigenous communities
Integration of genomic technology into healthcare settings establishes new capabilities to predict disease susceptibility and optimize treatment regimes. Yet, Indigenous peoples remain starkly underrepresented in genetic and clinical health research and are unlikely to benefit from such efforts. To foster collaboration with Indigenous communities, we propose six principles for ethical engagement in genomic research: understand existing regulations, foster collaboration, build cultural competency, improve research transparency, support capacity building, and disseminate research findings. Inclusion of underrepresented communities in genomic research has the potential to expand our understanding of genomic influences on health and improve clinical approaches for all populations.
Indigenous peoples are still underrepresented in genetic research. Here, the authors propose an ethical framework consisting of six major principles that encourages researchers and Indigenous communities to build strong and equal partnerships to increase trust, engagement and diversity in genomic studies.
Journal Article
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\"Discover the secret origins of the Triceratons: how they began on Earth, what that means for their return, and how they successfully rebelled against their Utrom captors! Plus, the Turtles fight to save their city, but become trapped in tight quarters when NYC is evacuated. Will they find a way to freedom without driving each other crazy? Then, Raphael and Alopex go undercover at Null Industries where they find more than they bargained for, including very angry mutants!\" --Amazon.com.
Book
Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors
The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. The mechanisms by which inhibition of SERT activity influences behavior are poorly understood. To address this question in the model organism
Drosophila melanogaster
, we developed new loss of function mutations in
Drosophila SERT
(
dSERT)
. Previous studies in both flies and mammals have implicated serotonin as an important neuromodulator of sleep, and our newly generated
dSERT
mutants show an increase in total sleep and altered sleep architecture that is mimicked by feeding the SSRI citalopram. Differences in daytime versus nighttime sleep architecture as well as genetic rescue experiments unexpectedly suggest that distinct serotonergic circuits may modulate daytime versus nighttime sleep.
dSERT
mutants also show defects in copulation and food intake, akin to the clinical side effects of SSRIs and consistent with the pleomorphic influence of serotonin on the behavior of
D
.
melanogaster
. Starvation did not overcome the sleep drive in the mutants and in male
dSERT
mutants, the drive to mate also failed to overcome sleep drive.
dSERT
may be used to further explore the mechanisms by which serotonin regulates sleep and its interplay with other complex behaviors.
Journal Article
Quantifying dislocation-type defects in post irradiation examination via transfer learning
The quantitative analysis of dislocation-type defects in irradiated materials is critical to materials characterization in the nuclear energy industry. The conventional approach of an instrument scientist manually identifying any dislocation defects is both time-consuming and subjective, thereby potentially introducing inconsistencies in the quantification. This work approaches dislocation-type defect identification and segmentation using a standard open-source computer vision model, YOLO11, that leverages transfer learning to create a highly effective dislocation defect quantification tool while using only a minimal number of annotated micrographs for training. This model demonstrates the ability to segment both dislocation lines and loops concurrently in micrographs with high pixel noise levels and on two alloys not represented in the training set. Inference of dislocation defects using transmission electron microscopy on three different irradiated alloys relevant to the nuclear energy industry are examined in this work with widely varying pixel noise levels and with completely unrelated composition and dislocation formations for practical post irradiation examination analysis. Code and models are available at
https://github.com/idaholab/PANDA
.
Journal Article
DEPDC5 takes a second hit in familial focal epilepsy
Loss-of-function mutations in a single allele of the gene encoding DEP domain-containing 5 protein (DEPDC5) are commonly linked to familial focal epilepsy with variable foci; however, a subset of patients presents with focal cortical dysplasia that is proposed to result from a second-hit somatic mutation. In this issue of the JCI, Ribierre and colleagues provide several lines of evidence to support second-hit DEPDC5 mutations in this disorder. Moreover, the authors use in vivo, in utero electroporation combined with CRISPR-Cas9 technology to generate a murine model of the disease that recapitulates human manifestations, including cortical dysplasia-like changes, focal seizures, and sudden unexpected death. This study provides important insights into familial focal epilepsy and provides a preclinical model for evaluating potential therapies.
Journal Article
A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans
Meiosis is a conserved tenet of sexual reproduction in eukaryotes, yet this program is seemingly absent from many extant species. In the human fungal pathogen
Candida albicans
, mating of diploid cells generates tetraploid products that return to the diploid state via a non-meiotic process of depolyploidization known as concerted chromosome loss (CCL). Here, we report that recombination rates are more than three orders of magnitude higher during CCL than during normal mitotic growth. Furthermore, two conserved ‘meiosis-specific’ factors play central roles in CCL as
SPO11
mediates DNA double-strand break formation while both
SPO11
and
REC8
regulate chromosome stability and promote inter-homolog recombination. Unexpectedly,
SPO11
also promotes DNA repair and recombination during normal mitotic divisions. These results indicate that
C. albicans
CCL represents a ‘parameiosis’ that blurs the conventional boundaries between mitosis and meiosis. They also reveal parallels with depolyploidization in mammalian cells and provide potential insights into the evolution of meiosis.
Mating of
Candida albicans
produces tetraploid products that return to the diploid state via a non-meiotic process known as concerted chromosome loss (CCL). Here, Anderson et al. show high recombination rates during CCL and identify factors that are essential for chromosome stability and recombination during CCL.
Journal Article
Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function
During vertebrate development, the presomitic mesoderm (PSM) periodically segments into somites, which will form the segmented vertebral column and associated muscle, connective tissue, and dermis. The periodicity of somitogenesis is regulated by a segmentation clock of oscillating Notch activity. Here, we examined mouse mutants lacking only
Fgf4
or
Fgf8
, which we previously demonstrated act redundantly to prevent PSM differentiation.
Fgf8
is not required for somitogenesis, but
Fgf4
mutants display a range of vertebral defects. We analyzed
Fgf4
mutants by quantifying mRNAs fluorescently labeled by hybridization chain reaction within Imaris-based volumetric tissue subsets. These data indicate that FGF4 maintains
Hes7
levels and normal oscillatory patterns. To support our hypothesis that FGF4 regulates somitogenesis through
Hes7
, we demonstrate genetic synergy between
Hes7
and
Fgf4
, but not with
Fgf8
. Our data indicate that
Fgf4
is potentially important in a spectrum of human Segmentation Defects of the Vertebrae caused by defective Notch oscillations.
Journal Article