Asset Details
Do you wish to reserve the book?
Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates
Do you wish to request the book?
Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates
2026
Overview
Candidozyma auris is a global human health threat because of its near-universal resistance to the antifungal fluconazole as well as a predisposition to multidrug resistance among clinical isolates. The underlying mechanisms of antifungal drug resistance in this species are still largely under investigation, and these efforts are significantly supported by research that increase our understanding of unique aspects of C. auris biology. We have identified a correlation between C. auris isolates’ susceptibility to fluconazole and intracellular drug accumulation in which drug-resistant isolates have significantly reduced intracellular fluconazole compared to isolates that are susceptible to fluconazole. We have proposed a mechanism for this phenomenon and demonstrated important roles for mutations in ERG11, TAC1B, and CDR1 gene sequences for drug resistance.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Antifungal Agents - metabolism
/ Antifungal Agents - pharmacology
/ Antifungal Resistance in Pathogenesis
/ C. auris
/ Candida auris - drug effects
/ Clinical Impact of Antifungal Resistance
/ Clinical Microbiology and Infectious Diseases
/ Complementarity-determining region 1
/ Cytochrome P-450 Enzyme System - genetics
/ Drug Resistance, Fungal - genetics
/ Enzymes
/ Fungal Drug Resistance Genes
/ Genes
/ Genomes
/ Humans
/ Mechanisms of Antifungal Resistance
/ Molecular and Cellular Biology
/ Mutation
/ Polymorphism, Single Nucleotide
/ Resistance in Emerging Fungal Pathogens
/ Single-nucleotide polymorphism
/ Sterols
