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The respiratory microbiome in pulmonary tuberculosis: a meta-analysis reveals niche-specific microbial and functional signatures
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The respiratory microbiome in pulmonary tuberculosis: a meta-analysis reveals niche-specific microbial and functional signatures
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Journal Article
The respiratory microbiome in pulmonary tuberculosis: a meta-analysis reveals niche-specific microbial and functional signatures
2026
Overview
Pulmonary tuberculosis (PTB) remains a leading cause of global mortality, yet the ecological principles shaping its respiratory microbiome are poorly understood. By integrating 16S rRNA datasets from upper and lower airway specimens, this study provides the first comprehensive meta-analysis of respiratory microbial diversity and function in PTB. We reveal distinct community structures and functional potentials among upper airways, sputum, and bronchoalveolar lavage fluid, driven by niche-specific ecological processes rather than stochastic assembly. These findings establish a baseline framework for interpreting microbial biogeography across the respiratory tract and highlight potential microbial biomarkers for site-specific monitoring and therapeutic targeting in PTB.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Alveoli
/ Bacteria - isolation & purification
/ Bronchoalveolar Lavage Fluid - microbiology
/ Bronchus
/ Clinical Microbiology and Infectious Diseases
/ Datasets
/ Genera
/ Humans
/ Lavage
/ meta
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Niches
/ Respiratory System - microbiology
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Sputum
/ Taxonomy
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