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Plasmid replication initiator protein TrfA represses the host type III secretion system in Pseudomonas aeruginosa
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Plasmid replication initiator protein TrfA represses the host type III secretion system in Pseudomonas aeruginosa
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Journal Article
Plasmid replication initiator protein TrfA represses the host type III secretion system in Pseudomonas aeruginosa
2025
Overview
As extrachromosomal elements, plasmids are well known for their role in conferring advantageous attributes to hosts, including antibiotic resistance, heavy metal resistance, the ability to degrade xenobiotics, and osmotolerance. Although several host chromosomally encoded proteins are required for the replication and maintenance of plasmids in their hosts, few proteins from plasmids have been reported to affect the host chromosomal gene expression. In this study, we identified TrfA, a plasmid replication initiation protein, as a novel repressor of the T3SS in P. aeruginosa . We also elucidated the regulatory mechanism of T3SS repression mediated by the TrfA. The significance of this work is in the identification of the replication initiation protein of a naturally occurring plasmid from P. aeruginosa functioning as a regulator of the expression of chromosomal genes in its host P. aeruginosa .
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Cloning
/ ExsA
/ Gene Expression Regulation, Bacterial
/ Genes
/ Humans
/ Mice
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Plasmids
/ Proteins
/ Pseudomonas aeruginosa - genetics
/ Pseudomonas aeruginosa - metabolism
/ Pseudomonas aeruginosa - pathogenicity
/ Pseudomonas Infections - microbiology
/ Regulation of Virulence Genes
/ Replication initiator protein
/ Transcriptional and Translational Control
/ TrfA
/ Type Iii Secretion System (T3ss)
/ Type III Secretion Systems - genetics
