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Desaminotyrosine promotes tuft cell expansion and integrates intestinal type 2 immunity
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Desaminotyrosine promotes tuft cell expansion and integrates intestinal type 2 immunity
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Journal Article
Desaminotyrosine promotes tuft cell expansion and integrates intestinal type 2 immunity
2026
Overview
A small molecule metabolite DAT drives tuft cell hyperplasia and type 2 immunity in the small intestine. DAT-mediated tuft cell hyperplasia depends on HDAC3 and an intact microbiota; our findings reveal how small molecule metabolites fine-tune intestinal type 2 defenses against parasites.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Cell Proliferation - drug effects
/ Histone Deacetylases - genetics
/ Histone Deacetylases - metabolism
/ Host-Microbiome Interactions
/ Immune System Modulation by Microbiota
/ Immunity
/ Intestinal epithelial cells (IECs)
/ Intestinal Mucosa - immunology
/ Intestine, Small - immunology
/ Mice
/ Microbial Pathogenesis and Immunology
/ Mucosal Microbiota and Immune Interactions
/ Proteins
