Journal Article

NEUROANATOMIC ABNORMALITIES IN ADOLESCENTS WITH GENERALIZED ANXIETY DISORDER: A VOXEL-BASED MORPHOMETRY STUDY

Strawn, Jeffrey R., Eliassen, James C., Cerullo, Michael A., Chu, Wen-Jang, Strakowski, Stephen M., Wehry, Anna M., DelBello, Melissa P., Adler, Caleb M.

2013

Overview

Background Despite recent data implicating functional abnormalities in the neurocircuitry underlying emotional processing in pediatric anxiety disorders, little is known regarding neurostructural abnormalities within these systems. Methods Using voxel‐based morphometry, gray and white matter volumes were compared in 15 medication‐free adolescents with generalized anxiety disorder (GAD; and no comorbid major depressive disorder) and 28 age‐ and sex‐matched healthy comparison subjects. Results Compared to healthy adolescents, youth with GAD had larger gray matter volumes in the right precuneus and right precentral gyrus and decreased gray matter volumes in the left orbital gyrus and posterior cingulate. White matter volumes were decreased in the left medial and superior frontal gyrus and were increased in the left inferior temporal gyrus in youth with GAD relative to healthy subjects. Conclusions Adolescents with GAD, who are early in the course of their illness, exhibit abnormalities in neural structures that subserve threat appraisal, modulation of fear responses, attachment, and mentalization.

• Publisher: Blackwell Publishing Ltd,John Wiley & Sons, Inc
• Subject: adolescence / Adolescent / Adolescents / Affect (Psychology) / Amygdala / Anxiety disorders / Anxiety Disorders - pathology / Brain - pathology / Brain Mapping / Case-Control Studies / Child / Comorbidity / Cortex (parietal) / Cross-sectional studies / Female / Fourier transforms / Frontal gyrus / Frontal Lobe - pathology / Generalized anxiety disorder / Gyrus Cinguli - pathology / Humans / Image Processing, Computer-Assisted / Magnetic Resonance Imaging / Male / Medical imaging / Mental depression / Morphometry / Nerve Fibers, Myelinated - pathology / Nerve Fibers, Unmyelinated - pathology / Neuroimaging / Neurophysiology / Organ Size / Parietal Lobe - pathology / Pediatrics / Post traumatic stress disorder / Precentral gyrus / Psychiatrists / Schizophrenia / Substantia alba / Substantia grisea / Teenagers / Temporal gyrus / Temporal Lobe - pathology / voxel-based morphometry