Asset Details
Do you wish to reserve the book?
Foxp2 deficiency impairs reproduction by modulating the hypothalamic–pituitary–gonadal axis in zebrafish
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Foxp2 deficiency impairs reproduction by modulating the hypothalamic–pituitary–gonadal axis in zebrafish
Do you wish to request the book?
Foxp2 deficiency impairs reproduction by modulating the hypothalamic–pituitary–gonadal axis in zebrafish
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Foxp2 deficiency impairs reproduction by modulating the hypothalamic–pituitary–gonadal axis in zebrafish
2024
Overview
FOXP2 was initially characterized as a transcription factor linked to speech and language disorders. Single-cell RNA sequencing reveals that Foxp2 is enriched in the gonadotrope cluster of the pituitary gland and colocalized with the hormones LHB and FSHB in chickens and mice, implying that FOXP2 might be associated with reproduction in vertebrates. Herein, we investigated the roles of foxp2 in reproduction in a Foxp2-deficient zebrafish model. The results indicated that the loss of Foxp2 inhibits courtship behavior in adult male zebrafish. Notably, Foxp2 deficiency disrupts gonad development, leading to retardation of follicle development and a decrease in oocytes in females at the full-growth stage, among other phenotypes. The transcriptome analysis (RNA-seq) also revealed that differentially expressed genes clustered into the estrogen signaling and ovarian steroidogenesis-related signaling pathways. In addition, we found that Foxp2 deficiency could modulate the hypothalamic–pituitary–gonadal axis, especially the regulation of lhb and fshb expression, in zebrafish. In contrast, the injection of human chorionic gonadotropin, a specific LH agonist, partially rescues Foxp2-impaired reproduction in zebrafish, suggesting that Foxp2 plays an important role in the regulation of reproduction via the hypothalamic–pituitary–gonadal axis in zebrafish. Thus, our findings reveal a new role for Foxp2 in the regulation of reproduction in vertebrates. Summary Sentence FOXP2, initially associated with speech and language disorders, is discovered to play a crucial role in vertebrate reproduction, affecting courtship behavior, gonad development, and the hypothalamic–pituitary–gonadal axis in zebrafish, shedding light on its broader biological functions.
Publisher
Society for the Study of Reproduction,Oxford University Press
Subject
/ agonists
/ Animals
/ Brain
/ CRISPR
/ Female
/ Females
/ Follicle-stimulating hormone
/ Forkhead Transcription Factors - genetics
/ Forkhead Transcription Factors - metabolism
/ Foxp2
/ Genes
/ HPG axis
/ human chorionic gonadotropin
/ Hypothalamic-Pituitary-Gonadal Axis
/ Hypothalamo-Hypophyseal System - metabolism
/ Male
/ males
/ Oocytes
/ Ovaries
/ Poultry
/ RNA
/ speech
/ Zebrafish Proteins - deficiency
