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Anticonvulsant-induced rickets and nephrocalcinosis
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Anticonvulsant-induced rickets and nephrocalcinosis
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Journal Article
Anticonvulsant-induced rickets and nephrocalcinosis
2025
Overview
Reported here is the case of a severely disabled young girl who developed Fanconi syndrome secondary to long-term valproic acid administration, ultimately leading to hypophosphatemic rickets. Although nephrocalcinosis is not a common feature in patients with proximal tubulopathy, the patient presented also with this condition, and the concomitant use of another anticonvulsant might have potentiated this condition. The purpose of this report is to increase awareness among healthcare providers of such rare but significant complications associated with anticonvulsants.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Acidosis
/ Anticonvulsants - adverse effects
/ Anticonvulsants - therapeutic use
/ Child
/ Fanconi Syndrome - chemically induced
/ Fanconi Syndrome - diagnosis
/ Female
/ Fructose - analogs & derivatives
/ Glucose
/ Humans
/ Kinases
/ Nephrocalcinosis - chemically induced
/ Nephrocalcinosis - diagnosis
/ Patients
/ Proteins
/ Reminder of Important Clinical Lesson
/ Rickets
/ Rickets - chemically induced
/ Urine
/ Valproic Acid - adverse effects
/ Valproic Acid - therapeutic use
/ White
/ X-rays
