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Prophylactic propranolol for prevention of ROP and visual outcome at 1 year (PreROP trial)
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Prophylactic propranolol for prevention of ROP and visual outcome at 1 year (PreROP trial)
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Journal Article
Prophylactic propranolol for prevention of ROP and visual outcome at 1 year (PreROP trial)
2017
Overview
ObjectiveTo evaluate the role of prophylactic propranolol in the prevention of retinopathy of prematurity (ROP) in infants ≤32 weeks of gestational age and their visual outcome at 1 year of corrected gestational age.DesignRandomised double blind placebo controlled trial, parallel group nrolment with allocation ratio of 1:1.SettingsTwo level III neonatal intensive care units.Participants109 preterm neonates of ≤32 weeks of gestation with postnatal age ≤8 days old.Intervention Study group: Infants with gestational age between 26 and 32 weeks were started on propranolol prophylaxis (0.5 mg/kg/dose every 12 hours) on seventh completed day of life, till a corrected gestational age of 37 weeks or complete vascularisation of retina whichever was later. Control group infants received a placebo.Outcome measures Primary: ROP of all grades; Secondary: evaluation of complications due to propranolol, ROP needing treatment with laser and/or antivascular endothelial growth factor (anti-VEGF) and visual outcome at 12 months corrected age.ResultsProphylactic propranolol in the prescribed dose of 1 mg/kg/day showed a decreasing trend in the incidence of ROP (56.8% vs 68.6%; p=0.39), need for laser therapy (21.56% vs 31.37%; p=0.37), treatment with anti-VEGF (3.92% vs 15.68%; p=0.09) or visual outcomes at 1 year in the study and control groups, respectively, though these reductions were not statistically significant. Decreasing trends favouring propranolol in all other ROP-related outcomes were also noted in the study group.ConclusionsProphylactic propranolol in the prescribed dose of 1 mg/kg/day showed a decreasing trend in all outcomes of ROP though statistically not significant.Trial registration numberCTRI/2013/11/004131.
Publisher
BMJ Publishing Group LTD
Subject
/ Babies
/ Drug Utilization - statistics & numerical data
/ Female
/ Humans
/ Infant
/ Infants
/ Intensive Care Units, Neonatal
/ Male
/ Neonates
/ Propranolol - administration & dosage
/ Retina
/ Retinopathy of Prematurity - epidemiology
/ Retinopathy of Prematurity - prevention & control
/ Vascular endothelial growth factor
/ Vascular Endothelial Growth Factors - antagonists & inhibitors
