Journal Article

Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension

Katsanos, Andreas, Tsai, James C, Voudouragkaki, Irini C, Floriani, Irene, Konstas, Anastasios G P, Haidich, Anna-Bettina, Giannopoulos, Theodoros, Riva, Ivano, Paschalinou, Eleni, Quaranta, Luciano

2013

Overview

Aim To compare 24 h intraocular pressure (IOP) control obtained with preservative free (PF) tafluprost 0.0015% versus branded preservative containing latanoprost 0.005% administered as first choice monotherapy in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT). Methods This prospective, observer-masked, crossover study included consecutive newly diagnosed patients with POAG or OHT, and baseline IOP between 24 and 33 mm Hg. Qualifying patients underwent baseline untreated 24 h IOP monitoring in habitual positions, with Goldmann tonometry at times 10:00, 14:00, 18:00 and 22:00, and Perkins supine tonometry at times 02:00 and 06:00. They were then randomised to either latanoprost or tafluprost, administered in the evening, for 3 months and then switched to the opposite therapy for another 3 months. 24 h monitoring was repeated at the end of each treatment period. Results 38 patients completed the study. Mean untreated 24 h IOP (24.9 mm Hg) was significantly reduced with both prostaglandins (p<0.001). Tafluprost demonstrated similar mean 24 h efficacy compared with latanoprost (17.8 vs 17.7 mm Hg; p=0.417). Latanoprost demonstrated significantly better 24 h trough IOP (15.9 vs 16.3 mm Hg; p=0.041) whereas tafluprost provided significantly lower 24 h IOP fluctuation (3.2 vs 3.8 mm Hg; p=0.008). No significant difference existed between the two prostaglandins for any adverse event. Conclusions PF tafluprost achieved similar 24 h IOP reduction to branded latanoprost. The current study highlights the importance of complete assessment of efficacy over 24 h. Clinical trials registration NCT01162603.

• Publisher: BMJ Publishing Group Ltd,BMJ Publishing Group LTD
• Subject: Aged / Antihypertensive Agents - administration & dosage / Antihypertensive Agents - adverse effects / Clinical Trial / Drugs / Female / Glaucoma / Glaucoma, Open-Angle - drug therapy / Humans / Hypertension / Intraocular pressure / Intraocular Pressure - drug effects / Long term / Male / Middle Aged / Ocular Hypertension - drug therapy / Patients / Preservatives, Pharmaceutical - administration & dosage / Preservatives, Pharmaceutical - adverse effects / Prospective Studies / Prostaglandins F - administration & dosage / Prostaglandins F - adverse effects / Prostaglandins F, Synthetic - administration & dosage / Prostaglandins F, Synthetic - adverse effects / Quality of life / Studies / Treatment Medical / Treatment Outcome