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Regulatory T-cell therapy in Crohn’s disease: challenges and advances
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Regulatory T-cell therapy in Crohn’s disease: challenges and advances
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Journal Article
Regulatory T-cell therapy in Crohn’s disease: challenges and advances
2020
Overview
The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn’s disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn’s disease.
Publisher
BMJ Publishing Group Ltd and British Society of Gastroenterology,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Antigens
/ Cell- and Tissue-Based Therapy - methods
/ Crohn Disease - drug therapy
/ Defects
/ Diabetes
/ Female
/ Humans
/ Intestinal Mucosa - drug effects
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - metabolism
/ Male
/ Mice
/ Mucosa
/ Recent Advances in Basic Science
