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Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
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Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
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Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
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Journal Article
Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study
2010
Overview
Objectives To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. Methods This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs and ultrasonography (US) at study entry. The rate of knee replacement surgery over the 3-year follow-up period was determined using Kaplan–Meier survival data analyses. Predictive factors for joint replacement were identified by univariate log-rank test then multivariate analysis using a Cox proportional-hazards regression model. Potential baseline predictors included demographic, clinical, radiographic and US features. Results Of the 600 original patients, 531 (88.5%), mean age 67±10 years, mean disease duration 6.1±6.9 years, had follow-up data and were analysed. During follow-up (median 3 years; range 0–4 years), knee replacement was done or required for 94 patients (estimated event rate of 17.7%). In the multivariate analysis, predictors of joint replacement were as follows: Kellgren and Lawrence radiographic grade (grade ≥III vs
Publisher
BMJ Publishing Group Ltd and European League Against Rheumatism,BMJ Publishing Group,Elsevier Limited,BMJ Group
Subject
/ Arthroplasty, Replacement, Knee
/ Biological and medical sciences
/ Diseases of the osteoarticular system
/ Exudates and Transudates - diagnostic imaging
/ Female
/ Humans
/ Knee
/ Knee Joint - diagnostic imaging
/ Male
/ Miscellaneous. Osteoarticular involvement in other diseases
/ Osteoarthritis, Knee - diagnostic imaging
/ Osteoarthritis, Knee - surgery
/ Patients
/ Sciences de la santé humaine
/ Studies
/ Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
