Journal Article

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

Meinzer, Ulrich, Galeotti, Caroline, Caseris, Marion, Chommeloux, Juliette, Haroche, Julien, Basmaci, Romain, Amoura, Zahir, Bader-Meunier, Brigitte, Borocco, Charlotte, Maroni, Arielle, Koné-Paut, Isabelle, Morelle, Guillaume, Bonacorsi, Stéphane, Carcelain, Guislaine, Deho, Anna, Bajolle, Fanny, Faye, Albert, Bensaid, Philippe, Pouletty, Marie, Ouldali, Naim, Pondarre, Corinne, Kouider, Hanane, Oualha, Mehdi, Craiu, Irina, Melki, Isabelle, Beyler, Constance, Pichard, Samia, Lachaume, Noémie

2020

Overview

BackgroundCurrent data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in the greater Paris region with a phenotype resembling Kawasaki disease (KD) has led to an alert by the French national health authorities.MethodsMulticentre compilation of patients with KD in Paris region since April 2020, associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (‘Kawa-COVID-19’). A historical cohort of ‘classical’ KD served as a comparator.ResultsSixteen patients were included (sex ratio=1, median age 10 years IQR (4·7 to 12.5)). SARS-CoV-2 was detected in 12 cases (69%), while a further three cases had documented recent contact with a quantitative PCR-positive individual (19%). Cardiac involvement included myocarditis in 44% (n=7). Factors prognostic for the development of severe disease (ie, requiring intensive care, n=7) were age over 5 years and ferritinaemia >1400 µg/L. Only five patients (31%) were successfully treated with a single intravenous immunoglobulin (IVIg) infusion, while 10 patients (62%) required a second line of treatment. The Kawa-COVID-19 cohort differed from a comparator group of ‘classical’ KD by older age at onset 10 vs 2 years (p<0.0001), lower platelet count (188 vs 383 G/L (p<0.0001)), a higher rate of myocarditis 7/16 vs 3/220 (p=0.0001) and resistance to first IVIg treatment 10/16 vs 45/220 (p=0.004).ConclusionKawa-COVID-19 likely represents a new systemic inflammatory syndrome temporally associated with SARS-CoV-2 infection in children. Further prospective international studies are necessary to confirm these findings and better understand the pathophysiology of Kawa-COVID-19. Trial registration number NCT02377245

• Publisher: Elsevier Limited,BMJ Publishing Group
• Subject: Adolescent / Age / Asthma / Betacoronavirus / Child / Child, Preschool / Children / Cohort Studies / Coronavirus Infections - diagnosis / Coronavirus Infections - epidemiology / Coronavirus Infections - virology / Coronaviruses / COVID-19 / Diagnosis, Differential / Epidemiology / Female / Heart diseases / Humans / Immunoglobulins / Infections / Inflammation / Influenza / Intensive care / Intravenous administration / Kawasaki disease / Life Sciences / Male / Mimicry / Mucocutaneous lymph node syndrome / Mucocutaneous Lymph Node Syndrome - diagnosis / Mucocutaneous Lymph Node Syndrome - virology / Multisystem inflammatory syndrome in children / Myocarditis / Overweight / Pandemics / Paris - epidemiology / Patients / Phenotypes / Pneumonia, Viral - diagnosis / Pneumonia, Viral - epidemiology / Pneumonia, Viral - virology / SARS-CoV-2 / Serology / Severe acute respiratory syndrome coronavirus 2 / Sex ratio / Systemic Inflammatory Response Syndrome - diagnosis / Systemic Inflammatory Response Syndrome - epidemiology / Systemic Inflammatory Response Syndrome - virology