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Occupational radiation exposure and excess additive risk of cataract incidence in a cohort of US radiologic technologists
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Occupational radiation exposure and excess additive risk of cataract incidence in a cohort of US radiologic technologists
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Occupational radiation exposure and excess additive risk of cataract incidence in a cohort of US radiologic technologists
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Journal Article
Occupational radiation exposure and excess additive risk of cataract incidence in a cohort of US radiologic technologists
2020
Overview
ObjectivesPrevious analyses of cataract in radiation-exposed populations have assessed relative risk; radiogenic excess additive risk (EAR), arguably of more public health importance, has not been estimated. Previous analysis of a large prospective cohort of US radiologic technologists (USRT) quantified excess relative risk of cataract in relation to occupational radiation dose. We aim to assess EARs of cataract.MethodsWe estimated EARs of cataract/cataract surgery in the USRT cohort using generalised additive models in relation to occupational radiation exposure, and assessed risk modification by a priori-selected cataract risk factors (diabetes, body mass index, smoking, race, sex, birth-year, ultraviolet B (UVB) radiation exposure).ResultsThere were 11 345 cataract diagnoses and 5440 of cataract surgery during 832 462 and 888 402 person-years of follow-up, respectively. Cumulative occupational radiation exposure was associated with self-reported cataract, but not with cataract surgery, with EAR/104 person-year Gy=94 (95% CI: 47 to 143, p<0.001) and EAR/104 person-year Gy=13 (95% CI: <0 to 57, p=0.551), respectively. There was marked (p<0.001) variation of EAR by age and by diabetes status, with risk higher among persons ≥75 years and diabetics. There were indications of elevated risk among those with higher UVB radiation (p=0.045), whites (p=0.056) and among those with higher levels of cigarette smoking (p=0.062). Elevated additive risk was observed for estimated occupational radiation eye-lens doses <100 mGy (p=0.004) with no dose–response curvature (p=0.903).ConclusionsThe elevated additive risks associated with low-dose radiation, if confirmed elsewhere, have important public health and clinical implications for radiation workers as well as regulatory measures.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD
Subject
/ Age
/ Diabetes
/ Ear
/ Eye lens
/ Female
/ Humans
/ Male
/ Occupational Diseases - epidemiology
/ Occupational Diseases - etiology
/ Occupational Exposure - adverse effects
/ Occupational Injuries - complications
/ Radiation Exposure - adverse effects
/ Radiation Injuries - epidemiology
/ Radiologists - statistics & numerical data
/ Smoking
/ Studies
/ Surgery
