Journal Article

Protocol of the SOMNIA project: an observational study to create a neurophysiological database for advanced clinical sleep monitoring

Pillen, Sigrid, van den Heuvel, Leonie, Lauwerijssen, Coen, Leufkens, Tim R, van Sloun, Ruud J G, Bergmans, Jan W M, van Dijk, Johannes P, Maass, Henning, Pevernagie, Dirk, van Gilst, Merel M, Hoondert, Bertram, Fonseca, Pedro, Overeem, Sebastiaan, Vandenbussche, Nele, Haakma, Reinder, Krijn, Roy, Arsenali, Bruno

2019

Overview

IntroductionPolysomnography (PSG) is the primary tool for sleep monitoring and the diagnosis of sleep disorders. Recent advances in signal analysis make it possible to reveal more information from this rich data source. Furthermore, many innovative sleep monitoring techniques are being developed that are less obtrusive, easier to use over long time periods and in the home situation. Here, we describe the methods of the Sleep and Obstructive Sleep Apnoea Monitoring with Non-Invasive Applications (SOMNIA) project, yielding a database combining clinical PSG with advanced unobtrusive sleep monitoring modalities in a large cohort of patients with various sleep disorders. The SOMNIA database will facilitate the validation and assessment of the diagnostic value of the new techniques, as well as the development of additional indices and biomarkers derived from new and/or traditional sleep monitoring methods.Methods and analysisWe aim to include at least 2100 subjects (both adults and children) with a variety of sleep disorders who undergo a PSG as part of standard clinical care in a dedicated sleep centre. Full-video PSG will be performed according to the standards of the American Academy of Sleep Medicine. Each recording will be supplemented with one or more new monitoring systems, including wrist-worn photoplethysmography and actigraphy, pressure sensing mattresses, multimicrophone recording of respiratory sounds including snoring, suprasternal pressure monitoring and multielectrode electromyography of the diaphragm.Ethics and disseminationThe study was reviewed by the medical ethical committee of the Maxima Medical Center (Eindhoven, the Netherlands, File no: N16.074). All subjects provide informed consent before participation.The SOMNIA database is built to facilitate future research in sleep medicine. Data from the completed SOMNIA database will be made available for collaboration with researchers outside the institute.

• Publisher: British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group
• Subject: Algorithms / Circadian rhythm / Clinical medicine / Comorbidity / Datasets / Electroencephalography / Heart rate / Insomnia / Medicine / Morphology / neurophysiology / Observational studies / polysomnography / Research Methods / Respiration / Sensors / Sleep apnea / Sleep disorders / sleep medicine