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Pathogen-targeting glycovesicles as a therapy for salmonellosis
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Pathogen-targeting glycovesicles as a therapy for salmonellosis
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Journal Article
Pathogen-targeting glycovesicles as a therapy for salmonellosis
2019
Overview
Antibiotic therapy is usually not recommended for salmonellosis, as it is associated with prolonged fecal carriage without reducing symptom duration or severity. Here we show that antibiotics encapsulated in hydrogen sulfide (H
2
S)-responsive glycovesicles may be potentially useful for the treatment of salmonellosis. The antibiotics are released in the presence of
Salmonella
, which is known to produce H
2
S. This approach prevents the quick absorption of antibiotics into the bloodstream, allows localized targeting of the pathogen in the gut, and alleviates disease symptoms in a mouse infection model. In addition, it reduces antibiotic-induced changes in the gut microbiota, and increases the abundance of potentially beneficial lactobacilli due to the release of prebiotic xylooligosaccharide analogs.
Antibiotic therapy is usually not effective for salmonellosis. Here, the authors present an approach that may be useful for the treatment of salmonellosis, consisting of hydrogen sulfide (H
2
S)-responsive glycovesicles that release antibiotics in the presence of
Salmonella
in the gut.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 140/131
/ 147/135
/ 45/23
/ 59
/ 64/60
/ Animals
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacokinetics
/ Anti-Bacterial Agents - pharmacology
/ Ciprofloxacin - pharmacokinetics
/ Ciprofloxacin - pharmacology
/ Female
/ Gastrointestinal Microbiome - drug effects
/ Gastrointestinal Microbiome - physiology
/ Humanities and Social Sciences
/ Hydrogen Sulfide - chemistry
/ Hydrogen Sulfide - pharmacokinetics
/ Hydrogen Sulfide - pharmacology
/ Mice
/ Oligosaccharides - chemistry
/ Oligosaccharides - metabolism
/ Salmonella Infections - drug therapy
/ Salmonella Infections - microbiology
/ Science
/ Therapy
