Asset Details
Do you wish to reserve the book?
FOXN1 mutation abrogates prenatal T-cell development in humans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
FOXN1 mutation abrogates prenatal T-cell development in humans
Do you wish to request the book?
FOXN1 mutation abrogates prenatal T-cell development in humans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
FOXN1 mutation abrogates prenatal T-cell development in humans
2011
Overview
BackgroundThe transcription factor FOXN1 is implicated in the differentiation of thymic and skin epithelial cells, and alterations in it are responsible for the Nude/SCID phenotype. During a genetic counselling programme offered to couples at risk in a community where a high frequency of mutated FOXN1 had been documented, the identification of a human FOXN1−/− fetus gave the unique opportunity to study T cell development in utero.ResultsTotal blockage of CD4+ T cell maturation and severe impairment of CD8+ cells were documented. Evaluation of the variable-domain β-chain (Vβ) families' usage among T lymphocytes revealed that the generation of T cell receptor (TCR) diversity occurred to some extent in the FOXN1−/− fetus, although it was impaired compared with the control. A few non-functional CD8+ cells, mostly bearing TCRγδ in the absence of CD3, were found.DiscussionFOXN1 is crucial for in utero T cell development in humans. The identification of a limited number of CD8+ cells suggests an extrathymic origin for these cells, implying FOXN1-independent lymphopoiesis.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Cell Differentiation - genetics
/ Cell Differentiation - immunology
/ Clinical genetics, Immunology (including allergy)
/ Female
/ Fetuses
/ Forkhead Transcription Factors - genetics
/ FOXN1
/ Humans
/ Immunology (including allergy)
/ Mutation
/ Proteins
/ Receptors, Antigen, T-Cell, gamma-delta - genetics
/ Receptors, Antigen, T-Cell, gamma-delta - immunology
/ Severe combined immunodeficiency
/ Severe Combined Immunodeficiency - embryology
/ Severe Combined Immunodeficiency - genetics
