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The Prognostic Value of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis
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The Prognostic Value of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis
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The Prognostic Value of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis
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Journal Article
The Prognostic Value of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis
2017
Overview
Previous clinical studies have found that the levels of tumor-infiltrating lymphocytes (TILs) significantly correlated with prognosis in hepatocellular carcinoma (HCC). However, these conclusions and data remain controversial. We performed a systematic review and meta-analysis to assess the prognostic value and clinical utilization of TILs in patients with HCC. A total of 23 relevant studies of 3173 patients were included into our meta-analysis. The results demonstrated that high levels of CD8
+
and CD3
+
TILs had a better prognostic value on overall survival (OS), with HRs of 0.71 (
P
= 0.04) and 0.63 (
P
= 0.03), respectively, compared to low levels, as did high levels of CD8
+
, CD3
+
and CD4
+
TILs on disease/recurrence-free survival (DFS/RFS), with HRs of 0.66 (
P
= 0.01), 0.60 (
P
= 0.01) and 0.79 (
P
= 0.04), respectively. In contrast, high levels of FoxP3
+
TILs had a worse prognostic value on OS and DFS/RFS, with HRs of 2.06 (
P
< 0.00001) and 1.77 (
P
< 0.00001), respectively. The FoxP3
+
/CD4
+
and FoxP3
+
/CD8
+
ratios negatively correlated with OS and DFS/RFS. These findings suggest that TILs may serve as a prognostic biomarker in HCC. However, further research should be performed to clarify the clinical value of TILs in HCC.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4020/4021/1607/1610/4029
/ Carcinoma, Hepatocellular - diagnosis
/ Carcinoma, Hepatocellular - immunology
/ Carcinoma, Hepatocellular - mortality
/ Carcinoma, Hepatocellular - pathology
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - pathology
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - pathology
/ Forkhead Transcription Factors - genetics
/ Forkhead Transcription Factors - immunology
/ Humanities and Social Sciences
/ Humans
/ Liver Neoplasms - immunology
/ Lymphocytes, Tumor-Infiltrating - immunology
/ Lymphocytes, Tumor-Infiltrating - pathology
/ Science
