Asset Details
Do you wish to reserve the book?
An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration
Do you wish to request the book?
An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration
2018
Overview
As a conductive nanomaterial, graphene has huge potentials in nerve function restoration by promoting electrical signal transduction and metabolic activities with unique topological properties. Polydopamine (PDA) and arginylglycylaspartic acid (RGD) can improve cell adhesion in tissue engineering. Here we report an integrated 3D printing and layer-by-layer casting (LBLC) method in multi-layered porous scaffold fabrication. The scaffold is composed of single-layered graphene (SG) or multi-layered graphene (MG) and polycaprolactone (PCL). The electrically conductive 3D graphene scaffold can significantly improve neural expression both in vitro and in vivo. It promotes successful axonal regrowth and remyelination after peripheral nerve injury. These findings implicate that graphene-based nanotechnology have great potentials in peripheral nerve restoration in preclinical and clinical application.
Graphene, as a conductive nanomaterial, has potential applications in the restoration of nerve function following physical injury. Here the authors design a graphene scaffold that can improve nerve regeneration.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 147/135
/ Animals
/ Biocompatible Materials - chemistry
/ Biocompatible Materials - pharmacology
/ Cell Adhesion - drug effects
/ Graphene
/ Humanities and Social Sciences
/ Male
/ Nerve Regeneration - drug effects
/ Nerve Regeneration - physiology
/ Oligopeptides - pharmacology
/ Peripheral Nerve Injuries - pathology
/ Peripheral Nerve Injuries - physiopathology
/ Peripheral Nerve Injuries - rehabilitation
/ Porosity
/ Rats
/ Regrowth
/ Schwann Cells - drug effects
/ Sciatic Nerve - drug effects
/ Science
