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Vitamin A Deprivation Results in Reversible Loss of Hippocampal Long-Term Synaptic Plasticity
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Vitamin A Deprivation Results in Reversible Loss of Hippocampal Long-Term Synaptic Plasticity
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Journal Article
Vitamin A Deprivation Results in Reversible Loss of Hippocampal Long-Term Synaptic Plasticity
2001
Overview
Despite its long history, the central effects of progressive depletion of vitamin A in adult mice has not been previously described. An examination of vitamin-deprived animals revealed a progressive and ultimately profound impairment of hippocampal CA1 long-term potentiation and a visual abolishment of long-term depression. Importantly, these losses are fully reversible by dietary vitamin A replenishment in vivo or direct application of all transretinoic acid to acute hippocampal slices. We find retinoid responsive transgenes to be highly active in the hippocampus, and by using dissected explants, we show the hippocampus to be a site of robust synthesis of bioactive retinoids. In aggregate, these results demonstrate that vitamin A and its active derivatives function as essential competence factors for long-term synaptic plasticity within the adult brain, and suggest that key genes required for long-term potentiation and long-term depression are retinoid dependent. These data suggest a major mental consequence for the hundreds of millions of adults and children who are vitamin A deficient.
Publisher
National Academy of Sciences,National Acad Sciences,The National Academy of Sciences
Subject
/ Adults
/ Aging
/ analysis
/ Animals
/ Biology
/ Brain
/ Child
/ Female
/ genetics
/ Humans
/ Long-Term Potentiation - physiology
/ Mice
/ Neuronal Plasticity - physiology
/ Receptors, Retinoic Acid - analysis
/ Receptors, Retinoic Acid - genetics
/ Receptors, Retinoic Acid - physiology
/ Rodents
/ Synapses
