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Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
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Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
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Journal Article
Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
2001
Overview
Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Antibodies, Monoclonal - immunology
/ Biological and medical sciences
/ Cells
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Genomics
/ Herpesviridae Infections - immunology
/ Histocompatibility Antigens Class I - immunology
/ Humans
/ Killer Cells, Natural - immunology
/ Ligands
/ Male
/ Membrane Glycoproteins - genetics
/ Membrane Glycoproteins - immunology
/ Mice
/ Muromegalovirus - immunology
/ Receptors, Immunologic - immunology
/ Receptors, NK Cell Lectin-Like
/ Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
/ Spleen
/ Virology
/ Viruses
