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bZIP factors of the Unfolded Protein Response interact with PIF4 to promote thermomorphogenesis
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bZIP factors of the Unfolded Protein Response interact with PIF4 to promote thermomorphogenesis
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Journal Article
bZIP factors of the Unfolded Protein Response interact with PIF4 to promote thermomorphogenesis
2025
Overview
When Arabidopsis plants are exposed to warm temperatures (e.g., 29 °C), they undergo adaptive growth known as thermomorphogenesis. This process is primarily regulated by the phytochrome B (phyB)-PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) module; however, the potential involvement of additional signaling pathways remains underexplored. Here, we show that warmth triggers endoplasmic reticulum (ER) stress, activating both arms of the Unfolded Protein Response (UPR). Three UPR-associated bZIP transcription factors, bZIP17, bZIP28 and bZIP60, promote hypocotyl growth under warmth in a PIF4-dependent manner. Active bZIP factors form complexes with PIF4 in the nucleus, where they bind to promoter regions of
PIF4
and other growth-related genes to enhance their expression. In parallel, bZIPs overexpression counteract the inhibitory effect of phyB on PIF4 stability, thereby reinforcing thermomorphogenic growth. Together, our findings define a regulatory axis that links ER stress, the UPR and thermomorphogenesis, clarifying how plants coordinate physiological and environmental cues to adapt to warming conditions.
UPR-derived bZIP factors interact with PIF4 to boost plant growth at moderately elevated temperatures, linking ER stress signaling with temperature-responsive pathways.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/15
/ 38/77
/ 82/1
/ 82/80
/ 82/83
/ Arabidopsis - growth & development
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics
/ Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism
/ Basic Helix-Loop-Helix Proteins - genetics
/ Basic Helix-Loop-Helix Proteins - metabolism
/ Basic-Leucine Zipper Transcription Factors - genetics
/ Basic-Leucine Zipper Transcription Factors - metabolism
/ Endoplasmic Reticulum Stress
/ Gene Expression Regulation, Plant
/ Humanities and Social Sciences
/ Hypocotyl - growth & development
/ Plants, Genetically Modified
/ Proteins
/ Science
