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Free-breathing multi-parametric SASHA (mSASHA) mapping provides reliable non-contrast myocardial characterization in a pediatric and adult congenital population
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Free-breathing multi-parametric SASHA (mSASHA) mapping provides reliable non-contrast myocardial characterization in a pediatric and adult congenital population
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Journal Article
Free-breathing multi-parametric SASHA (mSASHA) mapping provides reliable non-contrast myocardial characterization in a pediatric and adult congenital population
2025
Overview
Parametric mapping has become a standard of care technique for the non-invasive assessment of myocardial edema and fibrosis. Conventional MOLLI-based T1 mapping is susceptible to many confounding effects particularly in the pediatric population. The requirement for compliant breath holds is a major limitation for younger or more ill patients. The advent of free-breathing SASHA-based multi-parametric mapping with motion correction therefore offers a significant advantage in pediatric cohorts. With IRB approval and consent/assent, children and adults with congenital heart disease underwent both conventional breath-held MOLLI-based T1 and T2 TrueFISP mapping as well as free-breathing multi-parametric SASHA assessment in the context of a clinically indicated study on a 1.5T magnet. A total of 71 subjects with mean age of 19.3 ± 8.6 years were scanned. Free-breathing multiparametric SASHA T1 and T2 values were moderately correlated with breath-held MOLLI/T2p-bSSFP (
r
= 0.52). Importantly free-breathing SASHA-based T1 maps were able to discriminate between patients with late gadolinium enhancement with a statistically significant difference in mean T1 values (
p
= 0.03
). Free-breathing multiparametric SASHA allows for reliable myocardial characterization with moderate correlation to conventional breath-held T1 and T2 mapping techniques in a small and heterogenous sample of pediatric and congenital cardiac subjects.
Publisher
Springer Netherlands,Springer Nature B.V
Subject
/ Adult
/ Child
/ Contrast Media - administration & dosage
/ Edema
/ Edema, Cardiac - diagnostic imaging
/ Edema, Cardiac - physiopathology
/ Female
/ Fibrosis
/ Heart Defects, Congenital - complications
/ Heart Defects, Congenital - diagnostic imaging
/ Heart Defects, Congenital - pathology
/ Heart Defects, Congenital - physiopathology
/ Humans
/ Image Interpretation, Computer-Assisted - methods
/ Imaging
/ Infant
/ Magnetic Resonance Imaging - methods
/ Male
/ Mapping
/ Medicine
