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PD-L1hi B cells are critical regulators of humoral immunity
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Journal Article
PD-L1hi B cells are critical regulators of humoral immunity
2015
Overview
Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4
+
CXCR5
+
PD-1
+
follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to αCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases.
Follicular helper T cells promote antibody production by B cells, and regulatory B cells, in turn, can restrain T cell activation. Here, Khan
et al
. show that PD-L1 plays a critical role in regulatory B cell function, curbing excessive immune responses by engaging the PD-1 receptor on follicular helper T cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 13/21
/ 13/31
/ 64/60
/ 82/1
/ Adult
/ Animals
/ Antibodies, Monoclonal - chemistry
/ B-Lymphocytes, Regulatory - cytology
/ B-Lymphocytes, Regulatory - immunology
/ B7-H1 Antigen - biosynthesis
/ CD4-Positive T-Lymphocytes - cytology
/ Encephalomyelitis, Autoimmune, Experimental - immunology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Immunity, Humoral - immunology
/ Immunoglobulin G - immunology
/ Mice
/ Programmed Cell Death 1 Receptor - metabolism
/ Receptors, CXCR5 - metabolism
/ Science
