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SXR Rs3842689: a Prognostic Factor for Steroid Sensitivity or Resistance in Pediatric Idiopathic Nephrotic Syndrome

by Malaventura, Cristina , Edefonti, Alberto , Montini, Giovanni , Pugliese, Fabrizio , Turolo, Stefano , Lepore, Marta , Materassi, Marco , Decorti, Giuliana , Cuzzoni, Eva , Ghio, Luciana , Pasini, Andrea

in Adrenal Cortex Hormones - therapeutic use / Child / Child, Preschool / Corticosteroids / Deoxyribonucleic acid / Disease / DNA / Drug Resistance - genetics / Drugs / Female / Gene polymorphism / Genes / Genomics / Glycoproteins / Humans / Kidney diseases / Male / Metabolism / Nephrotic syndrome / Nephrotic Syndrome - drug therapy / Nephrotic Syndrome - genetics / Oxidoreductases Acting on Sulfur Group Donors - genetics / Pediatrics / Polymorphism / Polymorphism, Genetic - genetics / Predictive Value of Tests / Prognosis / Risk Factors / Steroids

2016

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SXR Rs3842689: a Prognostic Factor for Steroid Sensitivity or Resistance in Pediatric Idiopathic Nephrotic Syndrome

2016

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SXR Rs3842689: a Prognostic Factor for Steroid Sensitivity or Resistance in Pediatric Idiopathic Nephrotic Syndrome

2016

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Journal Article

SXR Rs3842689: a Prognostic Factor for Steroid Sensitivity or Resistance in Pediatric Idiopathic Nephrotic Syndrome

Malaventura, Cristina,

Edefonti, Alberto,

Montini, Giovanni,

Pugliese, Fabrizio,

Turolo, Stefano,

Lepore, Marta,

Materassi, Marco,

Decorti, Giuliana,

Cuzzoni, Eva,

Ghio, Luciana,

Pasini, Andrea

2016

Overview

of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution. Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity. The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.

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Publisher

Future Medicine Ltd

Subject

Adrenal Cortex Hormones - therapeutic use

/ Child

/ Child, Preschool

/ Corticosteroids

/ Deoxyribonucleic acid

/ Disease

/ DNA