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Unravelling the origins and forces that shape mtDNA mutations in human cells
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Journal Article
Unravelling the origins and forces that shape mtDNA mutations in human cells
2024
Overview
As we age, our cells acquire DNA mutations, resulting in cell-to-cell genomic heterogeneity. We characterized the landscape of mitochondrial DNA (mtDNA) heterogeneity in healthy human cells. Our observations provide deeper insight into the frequency of new mitochondrial mutations and the mechanisms that propagate low-level mutations in mtDNA over a lifetime.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
