Journal Article

Automating outcome analysis after stem cell transplantation: The YORT tool

Putter, Hein, Snowden, John A, Saccardi, Riccardo, Lankester, Arjan C, von Asmuth, Erik G. J, Schilham, Marco W, Mohseny, Alexander B

2023

Overview

Hematopoietic stem cell transplantation is a high-risk procedure. Auditing and yearly outcome reviews help keep optimal quality of care and come with increased survival, but also has significant recurring costs. When data has been entered in a standardized registry, outcome analyses can be automated, which reduces work and increases standardization of performed analyses. To achieve this, we created the Yearly Outcome Review Tool (YORT), an offline, graphical tool that gets data from a single center EBMT registry export, allows the user to define filters and groups, and performs standardized analyses for overall survival, event-free survival, engraftment, relapse rate and non-relapse mortality, complications including acute and chronic Graft vs Host Disease (GvHD), and data completeness. YORT allows users to export data as analyzed to allow you to check data and perform manual analyses. We show the use of this tool on a two-year single-center pediatric cohort, demonstrating how the results for both overall and event-free survival and engraftment can be visualized. The current work demonstrates that using registry data, standardized tools can be made to analyze this data, which allows users to perform outcome reviews for local and accreditation purposes graphically with minimal effort, and help perform detailed standardized analyses. The tool is extensible to be able to accommodate future changes in outcome review and center-specific extensions.

• Publisher: Nature Publishing Group
• Subject: Automation / Bone marrow / Complications / Data analysis / Graft-versus-host reaction / Hematopoietic stem cells / Pediatrics / Sound filters / Standardization / Stem cell transplantation / Stem cells / Survival / Transplantation