Journal Article

Contribution of Interleukin-10 Genotype to Triple Negative Breast Cancer Risk

CHEN, KAI-YUAN, TSAI, CHIA-WEN, SU, CHEN-HSIEN, BAU, DA-TIAN, LIAO, JIUAN-MIAW, WANG, HWEI-CHUNG, CHANG, WEN-SHIN, CHIEN, WEI-CHING, HSU, SHIH-WEI

2021

Overview

Triple negative breast cancer (TNBC) is characterized by increased recurrence and poor survival. Mounting evidence suggests that interleukin-10 (IL-10) plays a role in carcinogenesis, however, little is known about the contribution of IL-10 to TNBC. The study evaluated the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genotypes to the risk of TNBC. IL-10 genotypes were examined among 1,232 breast cancer patients and 1,232 controls and evaluated. The percentages of AG and GG for IL-10 A-1082G genotypes were higher in the breast cancer patient group than in the control group. The GG genotype carriers were of higher risk for breast cancer [odds ratio (OR)=2.02, 95% confidence interval (CI)=1.28-3.21, p=0.0021]. Interestingly, G allele carriers were of higher risk of TNBC (OR=1.25, 95%CI=1.07-1.46, p=0.0050). The G allele of IL-10 A-1082G genotype may serve as a predictor for TNBC risk. The finding should be validated in other populations.

• Publisher: International Institute of Anticancer Research
• Subject: Adult / Alcohol / Alleles / Biomarkers / Breast cancer / Carcinogenesis / Carcinogenesis - genetics / Carcinogens / Cigarettes / Cytokines / Female / Gastric cancer / Gene Frequency / Genetic Association Studies / Genetic Predisposition to Disease / Genotype / Genotype & phenotype / Genotypes / Health risks / Humans / Interleukin 10 / Interleukin-10 - genetics / Interleukins / Kidney cancer / Leukemia / Lung cancer / Medical prognosis / Middle Aged / Patients / Proteins / Risk / Risk Factors / Smoking / Triple Negative Breast Neoplasms - genetics / Triple Negative Breast Neoplasms - pathology