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Characterization and evaluation of the efficacy of phage E21 therapy in a wound animal model of biofilm-associated Pseudomonas aeruginosa infection
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Characterization and evaluation of the efficacy of phage E21 therapy in a wound animal model of biofilm-associated Pseudomonas aeruginosa infection
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Journal Article
Characterization and evaluation of the efficacy of phage E21 therapy in a wound animal model of biofilm-associated Pseudomonas aeruginosa infection
2026
Overview
Skin infections caused by strong biofilm
Pseudomonas aeruginosa (P. aeruginosa)
are considered a serious public health issue because of the increased resistance toward the currently available antibiotics. Consequently, innovative therapeutic strategies have emerged to address these challenging infections. Among them, phage therapy stands out, in which highly potent lytic bacteriophages (phages) are specifically selected to target and eradicate the responsible pathogens. In this study, Pseudomonas phage E21 was recovered from sewage, and it genetically belongs to the
Lavrentievirus
genus,
Casjensviridae
family. The genetic characterization of the isolated phage reveals the presence of highly potent lytic enzymes, which play a critical role in effectively suppressing the growth of the targeted pathogens. The phage has high stability patterns over a wide range of temperatures and pH values (65 ℃ and 3–11). Carboxymethylcellulose was used to formulate a hydrogel for the evaluation of the bacteriophage’s efficacy against biofilm-associated wound infection in a suitable animal model. The result of the preclinical study confirmed the efficacy of isolated phage in the therapy of biofilm-associated wound infection.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/61
/ Animals
/ Biofilms
/ Biofilms - growth & development
/ Enzymes
/ Genomes
/ Humanities and Social Sciences
/ Phages
/ Pseudomonas aeruginosa - physiology
/ Pseudomonas aeruginosa - virology
/ Pseudomonas Infections - microbiology
/ Pseudomonas Infections - therapy
/ Pseudomonas Phages - genetics
/ Pseudomonas Phages - isolation & purification
/ Pseudomonas Phages - physiology
/ Science
/ Sewage
