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Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis

by Conradie, Francesca , Frigati, Lisa , Martinson, Neil A. , Fairlie, Lee , Turner, Rebecca , Staples, Suzanne , Duong, Trinh , Batist, Elize , Nyamathe, Samukelisiwe , Schaaf, H. Simon , Gibb, Diana M. , Seddon, James A. , McGowan, Charlotte , Garcia-Prats, Anthony , Brigden, Joanna , Demers, Anne-Marie , Hesseling, Anneke C. , Purchase, Susan E. , Layton, Charlotte

in Adolescent / Adolescent Medicine / Adverse events / Age / Antibiotics / Antitubercular Agents - administration & dosage / Antitubercular Agents - adverse effects / Caregivers / Child / Child, Preschool / Childhood Diseases / Children / Disease prevention / Double-Blind Method / Drug dosages / Female / Global Health / HIV / HIV Infections - complications / Human immunodeficiency virus / Humans / Incidence / Infant / Infections / Infectious Disease / Infectious Disease General / Interferon-gamma Release Tests / Kaplan-Meier Estimate / Levofloxacin / Levofloxacin - administration & dosage / Levofloxacin - adverse effects / Male / Multidrug resistance / Mycobacterium tuberculosis - drug effects / Mycobacterium tuberculosis - immunology / Mycobacterium tuberculosis - isolation & purification / Patients / Pediatrics / Pediatrics General / Placebos / Sensitivity analysis / South Africa - epidemiology / Teenagers / Tuberculosis / Tuberculosis, Multidrug-Resistant - diagnosis / Tuberculosis, Multidrug-Resistant - drug therapy / Tuberculosis, Multidrug-Resistant - prevention & control / Tuberculosis, Multidrug-Resistant - transmission / Tuberculosis, Pulmonary - diagnosis / Tuberculosis, Pulmonary - drug therapy / Tuberculosis, Pulmonary - prevention & control / Tuberculosis, Pulmonary - transmission / γ-Interferon

2024

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Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis

2024

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2024

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Journal Article

Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis

Conradie, Francesca,

Frigati, Lisa,

Martinson, Neil A.,

Fairlie, Lee,

Turner, Rebecca,

Staples, Suzanne,

Duong, Trinh,

Batist, Elize,

Nyamathe, Samukelisiwe,

Schaaf, H. Simon,

Gibb, Diana M.,

Seddon, James A.,

McGowan, Charlotte,

Garcia-Prats, Anthony,

Brigden, Joanna,

Demers, Anne-Marie,

Hesseling, Anneke C.,

Purchase, Susan E.,

Layton, Charlotte

2024

Overview

In this randomized, controlled trial involving children with household exposure to multidrug-resistant tuberculosis, levofloxacin led to a lower incidence of tuberculosis than placebo, but the difference was not significant.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adolescent Medicine

/ Adverse events

/ Age

/ Antibiotics

/ Antitubercular Agents - administration & dosage

/ Antitubercular Agents - adverse effects