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Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures
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Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures
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Journal Article
Effects of Saccharina japonica Holdfast Powder on Microbiota in the Caecum of Mice Fed a High-Sucrose and Low-Fibre Diet and in Human Faecal Cultures
2023
Overview
The holdfast of
Saccharina japonica
(SjH) is a by-product of kombu cultivation and is rich in dietary fibres and phenolic compounds. SjH is regarded as a functional food material with anti-infection, immunomodulatory, and anti-viral effects. In this study, we aimed to examine SjH-responsive indigenous gut bacteria (SjH-RIB) in Institute of Cancer Research (ICR) mice fed a diet containing either no fibre or 5% (w w
−1
) SjH for 14 days. Additionally, we sought to determine the effects of SjH on organic acids, putrefactive compounds, and microbiota in human faecal cultures. Human stool samples collected from five healthy volunteers were incubated without (control) or with 2% (w w
−1
) SjH at 37 °C for 24 h. The microbiota in murine caecal samples and human faecal cultures were analysed via 16S rRNA (V4) amplicon sequencing. Compared to the mice fed no-fibre diets, mice fed SjH showed high caecal levels of
Clostridium
sensu stricto 1
-,
Oscillospiraceae spp.-,
Parabacteroides
spp.-, and
Alistipes
spp.-like bacteria. In contrast,
Allobaculum
, a dominant genus in the no-fibre group, was not detected in the SjH group. In human faecal cultures, the levels of acetate and propionate were higher in SjH-cultures than in the control cultures (
p
< 0.05). Furthermore, SjH-cultures showed low phenol contents. The genera
Bacteroides
,
Faecalibacterium
, and
Bifidobacterium
were more abundant in SjH-cultures than in the control cultures, although the abundance of each amplicon sequence variant in the SjH-RIB genera varied among individuals. These results suggest that the functions of SjH might be correlated with altered gut microbiota composition.
Graphical Abstract
Publisher
Springer Netherlands,Springer Nature B.V
Subject
