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Radioprotective Properties of Detoxified Lipid A from Salmonella minnesota R595
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Radioprotective Properties of Detoxified Lipid A from Salmonella minnesota R595
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Journal Article
Radioprotective Properties of Detoxified Lipid A from Salmonella minnesota R595
1986
Overview
In the past, the toxicity of bacterial lipopolysaccharide (LPS) or its principal bioactive component, lipid A, has detracted from their potential use as radioprotectants. Recently, a relatively nontoxic monophosphoryl Lipid A (LAM) that retains many of the immunobiologic properties of LPS has been isolated from a polysaccharide deficient Re mutant strain of Salmonella minnesota (R595). The ability of the native endotoxic glycolipid (GL) from S. minnesota (R595) as well as diphosphoryl lipid A (LAD) and nontoxic monophosphoryl lipid A (LAM) derived from GL to protect LPS responsive (CD2F1 or C3H/HeN) and nonresponsive (C3H/HeJ) mice from 60 Co γ irradiation has been studied. Administration of GL, LAD, or LAM to CD2F1 or C3H/HeN mice (400 μg/kg) 24 h prior to exposure provided significant radioprotection. No protection was afforded to C3H/HeJ mice. Experiments were also conducted to determine the relative abilities of GL, LAD, and LAM to stimulate hematopoiesis as reflected by the endogenous spleen colony (E-CFU) assay. Protection was not correlated with the ability of these substances to increase E-CFUs or to induce colony-stimulating activity (CSA).
Publisher
Academic Press, Inc,Radiation Research Society
Subject
/ Biological and medical sciences
/ Biological effects of radiation
/ Colony-Stimulating Factors - biosynthesis
/ Dosage
/ Endotoxins - therapeutic use
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Glycolipids - therapeutic use
/ Lipid A - analogs & derivatives
/ Lipids
/ Male
/ Mice
/ Radiation Injuries, Experimental - prevention & control
/ Radiation-Protective Agents - therapeutic use
/ Spleen
