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Gingival bleeding is a useful clinical feature in the diagnosis of hereditary bleeding disorders in children
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Gingival bleeding is a useful clinical feature in the diagnosis of hereditary bleeding disorders in children
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Journal Article
Gingival bleeding is a useful clinical feature in the diagnosis of hereditary bleeding disorders in children
2024
Overview
The search for hereditary bleeding disorders (HBD) prior to invasive procedures in children is primarily based on personal and family bleeding history. Although several scores are available, they have only been evaluated in specific situations or in adults. Our monocentric retrospective study aimed to analyze the association between clinical history and four scores (HEMSTOP, PBQ, ISTH-BAT, TOSETTO) and the diagnosis of MHC in children referred to the University Hospital of Montpellier for hemostasis investigations. A total of 117 children were retrospectively included in the study. Of these, 57 (49%) were diagnosed with HBD, with 30 having primary bleeding disorders and 27 having coagulation disorders. The diagnosis of HBD was significantly associated with gingival bleeding, which was present in 30% of HBD patients. In our population, only the HEMSTOP score showed an association with the diagnosis of HBD, but it was positive in only 48% of patients. By including gingival bleeding as a factor, we modified the HEMSTOP score, which increased its sensitivity from 0.45 to 0.53. When examining primary bleeding disorders, the modified HEMSTOP score, with the inclusion of gingival bleeding, enables us to diagnose 63% of patients (see Fig.
1
).
Conclusion
: Therefore, gingival bleeding should be considered a useful factor in bleeding history for HBD diagnosis. Adding this symptom to a screening score such as HEMSTOP improves its sensitivity. To confirm our findings, a prospective study is required.
Trial registration
: Study registration number: NCT05214300.
What is Known:
• Screening for hereditary bleeding disorder diseases is a necessity and a challenge in children.
• Minor disorders of primary hemostasis are the most common, but often escape standard coagulation tests.
What is New:
• Gingival bleeding is a frequent symptom that is easy to investigate and may point to a primary hemostasis disorder.
• Adding the gingival bleeding item to a routine screening score such as HEMSTOP improves sensitivity.
