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Improved Detection of the Sickle Mutation by DNA Analysis
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Improved Detection of the Sickle Mutation by DNA Analysis
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Journal Article
Improved Detection of the Sickle Mutation by DNA Analysis
1982
Overview
DETECTION of sickle hemoglobin in the human fetus was first accomplished nearly 10 years ago.
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This marked the beginning of a technology for prenatal diagnosis of the hemoglobinopathies. When methods for acquisition of fetal blood and for analysis of globin-chain synthesis were developed, the prenatal diagnosis of sickle-cell anemia and the thalassemia syndromes became a practical reality.
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Nearly 2000 fetuses at risk for these disorders have now been studied worldwide.
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However, a fetal loss of about 5 per cent due to these invasive procedures has provided the impetus for the development of diagnostic approaches that use fetal DNA rather than . . .
