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Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis
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Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis
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Journal Article
Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis
2016
Overview
We conducted a meta-analysis to explore the relationships between p14ARF gene methylation and clinicopathological features of colorectal cancer (CRC). Databases, including Pubmed, Embase and Cochrane Library, were searched and, finally, a total of 18 eligible researches encompassing 1988 CRC patients were selected. Combined odds ratios (ORs) with 95% confidence intervals (95% CIs) were evaluated under a fixed effects model for absence of heterogeneity. Significant associations were observed between p14ARF gene methylation and tumor location (OR = 2.35, 95% CI: 1.55-3.55, P = 0.001), microsatellite instability (MSI) status (OR = 3.28, 95% CI: 2.12-5.07, P<0.0001). However, there were no significant associations between p14ARF gene methylation and tumor stage, tumor differentiation. We concluded that p14ARF gene methylation may be significantly associated with tumor location, and MSI status of CRC.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Cancer
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - pathology
/ Computer and Information Sciences
/ DNA
/ Female
/ Genes
/ Humans
/ Male
/ Medicine and Health Sciences
/ Oncology
/ Proteins
/ Research and Analysis Methods
/ Studies
/ Tumor Suppressor Protein p14ARF - genetics
/ Tumors
