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Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

by Niu, Simiao , Jing, Serena , Rodrigues, Melanie , Chen, Kellen , Larson, Madelyn R. , Saberi, Aref , Leeolou, Melissa C. , Zhang, Kailiang , Steele, Sydney R. , Snyder, Michael P. , Trotsyuk, Artem A. , Sivaraj, Dharshan , Januszyk, Michael , Bonham, Clark A. , Gurtner, Geoffrey C. , Chattopadhyay, Arhana , Neimeth, Christopher R. , Gurusankar, Gurupranav , Beard, Ethan , Padmanabhan, Jagannath , Henn, Dominic , Lai, Jian-Cheng , Perrault, David P. , Kussie, Hudson C. , Fischer, Katharina S. , Nag, Ronjon , Mittal, Smiti , Zhong, Donglai , Bao, Zhenan , Jain, Tanish , Zhao, Eric , Sun, Kefan , Viana, Willian G. , Maan, Zeshaan N. , Liang, Kui , Jiang, Yuanwen , Tang, Jing , Shih, Chien-Chung , Kwon, Sun Hyung , Mermin-Bunnell, Alana M.

in 639/166/985 / 639/301/923/1027 / 692/308/2778 / 692/699/578 / 692/700/565 / Adhesion / Agriculture / Animals / Bandages / Bioelectricity / Bioinformatics / Biomedical and Life Sciences / Biomedical Engineering/Biotechnology / Biomedicine / Biotechnology / Closed loops / Electrical stimuli / Electrodes / Environment models / Hydrogels / Life Sciences / Macrophages / Medical dressings / Mice / Monitoring, Physiologic / Monocytes / Regeneration (physiology) / Sensors / Signal transduction / Skin / Stimulation / Stimulators / Tissue engineering / Transcription activation / Vascularization / Wearable Electronic Devices / Wearable technology / Wound Healing

2023

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2023

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2023

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Journal Article

Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Niu, Simiao,

Jing, Serena,

Rodrigues, Melanie,

Chen, Kellen,

Larson, Madelyn R.,

Saberi, Aref,

Leeolou, Melissa C.,

Zhang, Kailiang,

Steele, Sydney R.,

Snyder, Michael P.,

Trotsyuk, Artem A.,

Sivaraj, Dharshan,

Januszyk, Michael,

Bonham, Clark A.,

Gurtner, Geoffrey C.,

Chattopadhyay, Arhana,

Neimeth, Christopher R.,

Gurusankar, Gurupranav,

Beard, Ethan,

Padmanabhan, Jagannath,

Henn, Dominic,

Lai, Jian-Cheng,

Perrault, David P.,

Kussie, Hudson C.,

Fischer, Katharina S.,

Nag, Ronjon,

Mittal, Smiti,

Zhong, Donglai,

Bao, Zhenan,

Jain, Tanish,

Zhao, Eric,

Sun, Kefan,

Viana, Willian G.,

Maan, Zeshaan N.,

Liang, Kui,

Jiang, Yuanwen,

Tang, Jing,

Shih, Chien-Chung,

Kwon, Sun Hyung,

Mermin-Bunnell, Alana M.

2023

Overview

‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery. A wireless ‘smart’ bandage stimulates wound healing.

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Nature Publishing Group US,Nature Publishing Group

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