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Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics
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Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics
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Journal Article
Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics
2024
Overview
Although charge-converting nanoparticles (NPs) potentially penetrate tumours deeply, conventional charge conversion strategies possess limitations, including low selectivity and slow, inconsistent conversion rate within the tumour microenvironment. In this study, we synthesized a zwitterionic near-infrared cyclodextrin derivative of heptamethine cyanine and complexed it with pheophorbide-conjugated ferrocene to produce multifunctional theranostic nanotherapeutics. Our NPs demonstrated enhanced tumour-targeting ability, enabling the highly specific imaging of rectal tumours, with tumour-to-rectum signal ratios reaching up to 7.8. The zwitterionic surface charge of the NPs was rapidly converted to a cationic charge within the tumours on 880 nm near-infrared laser irradiation, promoting the tumoural penetration of NPs via transcytosis. After penetration, photodynamic/chemodynamic therapy was initiated using a 660 nm laser. Our NPs eradicated clinically relevant-sized heterotopic tumours (~250 mm
3
) and orthotopic rectal tumours, displaying their potential as theranostic nanoplatforms for targeting rectal cancer.
The photobleaching property of heptamethine cyanine enables efficient charge conversion of nanoparticles. Here heptamethine-cyanine-based nanoparticles achieve specific tumour imaging, deep tumour penetration and high therapeutic efficacy in rectal cancer animal models.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Cancer
/ Carbocyanines - pharmacokinetics
/ Chemistry and Materials Science
/ Female
/ Ferrous Compounds - chemistry
/ Humans
/ Mice
/ Nanoparticles - therapeutic use
/ Nanotechnology and Microengineering
/ Rectal Neoplasms - diagnostic imaging
/ Rectal Neoplasms - pathology
/ Rectum
/ Theranostic Nanomedicine - methods
/ Tumors
