Journal Article

Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population

Sakai, Daisuke, Kakutani, Kenichiro, Kakiuchi, Yuji, Eto, Fumihiko, Kaito, Takashi, Seki, Shoji, Terashima, Yoshinori, Kuroda, Akiyoshi, Funao, Haruki, Kato, Kenji, Terai, Hidetomi, Oshima, Yasushi, Otsuki, Bungo, Watanabe, Kota, Suzuki, Hidenori, Yunde, Atsushi, Iizuka, Yoichi, Nakashima, Hiroaki, Uehara, Masashi, Nakanishi, Kazuo, Inoue, Gen, Takeda, Kazuki, Kato, Satoshi, Hashimoto, Ko, Imajo, Yasuaki, Segi, Naoki, Kawaguchi, Kenichi, Akeda, Koji, Yamada, Tomohiro, Ikegami, Shota, Tokumoto, Hiroto, Miyazaki, Masashi, Suzuki, Nobuyuki, Onoda, Yoshito, Tominaga, Hiroyuki, Tonomura, Hitoshi, Takasawa, Eiji, Haruta, Yohei, Funayama, Toru, Nakamura, Hiroaki, Ohba, Tetsuro, Okada, Seiji, Tamai, Koji, Sakata, Munehiro, Yamaji, Akihiro, Imagama, Shiro, Misaki, Kosuke, Furuya, Takeo, Sawada, Hirokatsu, Hasegawa, Tomohiko, Uei, Hiroshi, Nakajima, Hideaki, Kiyasu, Katsuhito, Yokogawa, Noriaki, Yamane, Junichi, Sasagawa, Takeshi, Hirota, Ryosuke, Yoshii, Toshitaka, Ito, Sadayuki, Takegami, Norihiko, Ishihara, Masayuki

2024

Overview

Study designRetrospective cohort study.ObjectivesTo define the prognosis and predictive factors for neurological improvement in older patients with incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale grade C (AIS-C).SettingsMulti-institutions in Japan.MethodsWe included patients aged ≥65 years with traumatic SCI of AIS-C who were treated conservatively or surgically with >3 follow-up months. To identify factors related to neurological improvement, patients were divided into three groups according to their neurological status at the final follow-up, with univariate among-group comparisons of demographics, radiographic, and therapeutic factors. Significant variables were included in the multivariate logistic regression analysis.ResultsOverall, 296 older patients with SCI of AIS-C on admission were identified (average age: 75.2 years, average follow-up: 18.7 months). Among them, 190 (64.2%) patients improved to AIS-D and 21 (7.1%) patients improved to AIS-E at final follow-up. There were significant among-group differences in age (p = 0.026), body mass index (p = 0.007), status of pre-traumatic activities of daily living (ADL) (p = 0.037), and serum albumin concentrations (p = 0.011). Logistic regression analysis showed no significant differences in variables in the stratified group of patients who improved to AIS-D. Meanwhile, serum albumin was a significant variable in patients who improved to AIS-E (p = 0.026; OR: 6.20, pre-traumatic ADL was omitted due to data skewness).ConclusionsMost older patients with incomplete AIS-C SCI demonstrated at least 1 grade of neurological improvement. However, <10% of patients achieved complete recovery. Key predictors of complete recovery were high serum albumin levels on admission and independent pre-traumatic ADL.SponsorshipNo funding was received for this study.

• Publisher: Nature Publishing Group
• Subject: Activities of daily living / Albumin / Body mass index / Body size / Demographic variables / Demographics / Population studies / Proteins / Recovery / Regression analysis / Serum albumin / Spinal cord injuries