Journal Article

Sleep disturbance is associated with worsening quality of life in patients with multiple system atrophy

Komatsu, Teppei, Mitsumura, Hidetaka, Murakami, Hidetomo, Sengoku, Renpei, Sarukawa, Hiroki, Matsuno, Hiromasa, Bono, Keiko, Okumura, Motohiro, Masui, Marina, Motegi, Haruhiko, Shiraishi, Tomotaka, Shimizu, Hideyuki, Sakai, Kenichiro, Ozawa, Masakazu, Okano, Hirotaka James, Kida, Hiroyuki, Umehara, Tadashi, Sakuta, Kenichi, Omoto, Shusaku, Iguchi, Yasuyuki

2025

Overview

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by parkinsonism, cerebellar ataxia, autonomic dysfunction, and sleep disturbances, such as rapid eye movement sleep behavior disorder (RBD). The association between sleep disturbances, including RBD, and decreased quality of life (QOL) in patients with MSA has not been elucidated. We aimed, therefore, to evaluate this association in individuals with MSA. We assessed a total of 34 patients with MSA (44.1 % male; 61.8 % MSA with predominant cerebellar ataxia) for sleep disturbances, RBD, and QOL using the Parkinson’s Disease Sleep Scale-2 (PDSS-2), RBD Screening Questionnaire (RBDSQ), and Parkinson’s Disease Questionnaire-39 (PDQ-39). Multiple regression analyses were conducted with the Summary Index (SI) of PDQ-39 total and each domain as dependent variable and age, sex, urinary dysfunction, and the PDSS-2 total, sleep, motor, parkinsonism, and the RBDSQ scores as independent variables. The rate of PDSS-2 scores ≥ 15 was 41.2 %, while that of RBDSQ scores ≥ 5 was 17.6 %. Multiple regression analyses revealed that the PDSS-2 total score significantly contributed to increase in the SI of PDQ-39 total (β = 0.646, P < 0.001), mobility (β = 0.663, P < 0.001), activities of daily living (β = 0.650, P < 0.001), emotional well-being (β = 0.426, P = 0.019), and bodily discomfort (β = 0.566, P < 0.001). We demonstrated a strong relationship between the sleep disturbances and worsening QOL in patients with MSA. Healthcare providers should also focus on sleep disturbances when managing patients with MSA. •Patients with MSA often develop sleep disturbances such as RBD.•Sleep disturbance and quality of life were strongly correlated in patients with MSA.•Healthcare providers should focus on sleep disturbances when managing MSA patients.

• Publisher: Elsevier B.V,Elsevier Limited
• Subject: Activities of daily living / Aged / Ataxia / Atrophy / Autonomic nervous system / Basal ganglia / Blood pressure / Central nervous system diseases / Cerebellar ataxia / Cerebellum / Constipation / Female / Humans / Hypertension / Likert scale / Male / Middle Aged / Movement disorders / Multiple system atrophy / Multiple System Atrophy - complications / Multiple System Atrophy - psychology / Neurodegenerative diseases / Neurology / Neurosurgery / Parkinson's disease / Quality of life / Quality of Life - psychology / Questionnaires / Rapid eye movement sleep behavior disorder / Regression analysis / REM sleep / REM Sleep Behavior Disorder - etiology / REM Sleep Behavior Disorder - psychology / Restless legs syndrome / Sleep / Sleep disorders / Sleep disturbance / Sleep Wake Disorders - etiology / Sleep Wake Disorders - psychology / Social support / Surveys and Questionnaires / Variables / Well being