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Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza

by Hurt, Aeron C. , Katugampola, Laurie , Lauring, Adam S. , Kuhlbusch, Klaus , Wildum, Steffen , Bernasconi, Corrado , McLean, Barry , Cowling, Benjamin J. , Takazono, Takahiro , Cao, Bin , Widmer, Andreas , Graham, Emily , Cohen, Herman Avner , Monto, Arnold S. , Kamezawa, Takashi

in Administration, Oral / Adolescent / Adolescent Medicine / Adult / Age / Antigens / Antiviral Agents - administration & dosage / Antiviral Agents - adverse effects / Antiviral drugs / Child / Child, Preschool / Childhood Diseases / COVID-19 / Dibenzothiepins - administration & dosage / Dibenzothiepins - adverse effects / Disease prevention / Disease transmission / Double-Blind Method / Drug dosages / Drug resistance / Drug Resistance, Viral / Enrollments / Exo-a-sialidase / Family Characteristics / Female / Global Health / Households / Humans / Immunization / Incidence / Infectious Disease / Infectious Disease General / Influenza / Influenza A virus - drug effects / Influenza A virus - isolation & purification / Influenza B virus - drug effects / Influenza B virus - isolation & purification / Influenza, Human - drug therapy / Influenza, Human - epidemiology / Influenza, Human - prevention & control / Influenza, Human - transmission / Male / Middle Aged / Morpholines - administration & dosage / Morpholines - adverse effects / Pandemics / Patients / Pediatrics / Pediatrics General / Placebos / Public Health / Public Health General / Pyridones - adverse effects / Pyridones - therapeutic use / Severe acute respiratory syndrome coronavirus 2 / Triazines - administration & dosage / Triazines - adverse effects / Vaccines / Viral Infections / Virus Shedding - drug effects / Viruses / Young Adult

2025

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2025

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2025

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Journal Article

Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza

Hurt, Aeron C.,

Katugampola, Laurie,

Lauring, Adam S.,

Kuhlbusch, Klaus,

Wildum, Steffen,

Bernasconi, Corrado,

McLean, Barry,

Cowling, Benjamin J.,

Takazono, Takahiro,

Cao, Bin,

Widmer, Andreas,

Graham, Emily,

Cohen, Herman Avner,

Monto, Arnold S.,

Kamezawa, Takashi

2025

Overview

In this randomized trial conducted over the 2019–2024 influenza seasons, baloxavir resulted in a significantly lower incidence of transmission of influenza virus from patients to household contacts than placebo.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Adolescent

/ Adolescent Medicine

/ Adult

/ Age

/ Antigens

/ Antiviral Agents - administration & dosage