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Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn

by Leu, Jocelyn H. , Markham, Kara , Tjoa, May Lee , Ling, Leona E. , Miller, Russell S. , Ocón-Hernández, Olga , Moise, Kenneth J. , Lopriore, Enrico , Sachs, Ulrich J. , Norton, Mary E. , Devlieger, Roland , Schwartz, Lisa B. , Bussel, James B. , Pereira, Leonardo , Oepkes, Dick , Tiblad, Eleonor , Streisand, James B. , Mirza, Arpana , Bein, Gregor , Smoleniec, John , Pandya, Pranav , Windrim, Rory , Emery, Stephen P. , Saeed-Khawaja, Shumyla , Kilby, Mark D. , Verweij, E.J.T. Joanne , Komatsu, Yosuke , Silver, Robert M. , Audibert, François , Smith, Valerie

in Adult / Age / Alloantibodies / Anemia / Anemia - immunology / Anemia - prevention & control / Antibodies, Monoclonal, Humanized - administration & dosage / Antibodies, Monoclonal, Humanized - adverse effects / Antigens / Apheresis / Babies / Birth / Blood levels / Blood Transfusion, Intrauterine - adverse effects / Body weight / Complications of Pregnancy / Cord blood / Disease prevention / Edema / Erythroblastosis, Fetal - blood / Erythroblastosis, Fetal - immunology / Erythroblastosis, Fetal - therapy / Fc receptors / Female / Fetuses / Gestational Age / Gynecology / Hematology / Hemoglobin / Hemolytic disease / Histocompatibility Antigens Class I / Humans / Hydrops Fetalis - immunology / Hydrops Fetalis - prevention & control / Immunoglobulin G / Immunoglobulin G - immunology / Infant, Newborn / Infusions, Intravenous / Isoantibodies - blood / Isoantibodies - immunology / Live Birth / Neonates / Neonatology / Newborn babies / Obstetrics / Oncology / Pediatrics / Pediatrics General / Pharmacodynamics / Pregnancy / Receptors, Fc - antagonists & inhibitors / Receptors, Fc - blood / Receptors, Fc - immunology / Ultrasonic imaging

2024

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Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn

2024

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2024

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Journal Article

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn

Leu, Jocelyn H.,

Markham, Kara,

Tjoa, May Lee,

Ling, Leona E.,

Miller, Russell S.,

Ocón-Hernández, Olga,

Moise, Kenneth J.,

Lopriore, Enrico,

Sachs, Ulrich J.,

Norton, Mary E.,

Devlieger, Roland,

Schwartz, Lisa B.,

Bussel, James B.,

Pereira, Leonardo,

Oepkes, Dick,

Tiblad, Eleonor,

Streisand, James B.,

Mirza, Arpana,

Bein, Gregor,

Smoleniec, John,

Pandya, Pranav,

Windrim, Rory,

Emery, Stephen P.,

Saeed-Khawaja, Shumyla,

Kilby, Mark D.,

Verweij, E.J.T. Joanne,

Komatsu, Yosuke,

Silver, Robert M.,

Audibert, François,

Smith, Valerie

2024

Overview

In a trial involving 13 pregnancies at high risk for early-onset severe hemolytic disease of the fetus and newborn, nipocalimab increased the percentage with live birth at 32 weeks’ gestation or later without intrauterine transfusions.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Age

/ Alloantibodies

/ Anemia

/ Anemia - immunology

/ Anemia - prevention & control

/ Antibodies, Monoclonal, Humanized - administration & dosage