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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion
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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion
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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion
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Journal Article
Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion
2015
Overview
To compare the efficacy of two treatment regimens among Helicobacter pylori stool antigen positive children suffering from resistant otitis media with effusion.
The study comprised 258 children with bilateral otitis media with effusion; 134 were positive for H pylori stool antigen, and were equally and randomly allocated to the control group or study group. The control group received standard otitis media with effusion therapy (amoxicillin and clavulanate), while the study group received standard H pylori triple therapy (clarithromycin, metronidazole and lansoprazole).
In the control group, there was a marked clinical response to treatment in 33 of the 67 children (49.3 per cent). In the study group, there was a marked response in a significantly higher number of children (46 out of 67, 68.7 per cent). The 124 H pylori stool antigen negative children not included in the 2 aforementioned groups received amoxicillin and clavulanate, and a marked response in symptoms was evident in 98 of these children (79 per cent).
H pylori infection may lead to resistance to traditional otitis media with effusion treatment in some cases. H pylori eradication is associated with a high cure rate.
Publisher
Cambridge University Press
Subject
/ Anti-Bacterial Agents - therapeutic use
/ Antigens
/ Antigens, Bacterial - isolation & purification
/ Child
/ Clarithromycin - therapeutic use
/ Clavulanic Acid - therapeutic use
/ Female
/ Helicobacter Infections - complications
/ Helicobacter Infections - drug therapy
/ Helicobacter pylori - immunology
/ Helicobacter pylori - isolation & purification
/ Humans
/ Lansoprazole - therapeutic use
/ Male
/ Metronidazole - therapeutic use
/ Otitis Media with Effusion - complications
/ Otitis Media with Effusion - drug therapy
/ Otitis Media with Effusion - microbiology
