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Induction of Acute Pleural Inflammation by Staphylococcus aureus. I. CD4+ T Cells Play a Critical Role in Experimental Empyema
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Induction of Acute Pleural Inflammation by Staphylococcus aureus. I. CD4+ T Cells Play a Critical Role in Experimental Empyema
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Induction of Acute Pleural Inflammation by Staphylococcus aureus. I. CD4+ T Cells Play a Critical Role in Experimental Empyema
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Journal Article
Induction of Acute Pleural Inflammation by Staphylococcus aureus. I. CD4+ T Cells Play a Critical Role in Experimental Empyema
2000
Overview
Bacterial empyema is a frequent complication of pneumonia in patients with acquired immunodeficiency syndrome (AIDS). A model of Staphylococcus aureus empyema was developed that closely resembles bacterial empyema in patients infected with human immunodeficiency virus (HIV). Results show a compartmentalized chemokine response in bacterial empyema. The chemokine levels were higher in the pleural compartment than in the peripheral circulation. Polymorphonuclear leukocyte counts, murine GRO-α (KC), and macrophage inflammatory protein—2 levels were significantly (P < .001) lower in CD4+ knockout (CD4 KO) mice pleural fluid than in CD4+ wild-type (CD4 WT) mice. The CD4 KO mice had poorer bacterial clearance than CD4 WT mice. During S. aureus infection, interleukin-10 levels increased in the CD4 KO mice, whereas interferon-γ levels were increased in CD4 WT mice. CD4+ T cell depletion results in a decreased pleural chemokine response, decreased neutrophil influx into pleural space, and impaired bacterial clearance in empyema.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Animals
/ Bacteria
/ Biological and medical sciences
/ CD4-Positive T-Lymphocytes - immunology
/ Chemotactic Factors - analysis
/ Empyema
/ Empyema, Pleural - immunology
/ Empyema, Pleural - microbiology
/ Experimental bacterial diseases and models
/ Female
/ Growth Substances - analysis
/ HIV Infections - complications
/ Humans
/ Intercellular Signaling Peptides and Proteins
/ Mice
