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Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

by Rugo, Hope S , Mina, Lida A , Roché, Henri , Tudor, Iulia C , Im, Young-Hyuck , Fehrenbacher, Louis , Blum, Joanne L , Eiermann, Wolfgang , Lee, Kyung-Hun , Yerushalmi, Rinat , Gonçalves, Anthony , Martin, Miguel , Litton, Jennifer K , Hurvitz, Sara A , Ettl, Johannes , Quek, Ruben G.W , Markova, Denka , Hannah, Alison L

in Adenosine / Adult / Aged / Aged, 80 and over / Antineoplastic Agents - adverse effects / Antineoplastic Agents - therapeutic use / Antitumor activity / Apoptosis / BRCA1 protein / BRCA2 protein / Breast cancer / Breast Neoplasms - drug therapy / Breast Neoplasms - genetics / Cancer therapies / Chemotherapy / Consent / Cytotoxicity / Deoxyribonucleic acid / Disease-Free Survival / DNA / Drug dosages / Female / Gemcitabine / Genes, BRCA1 / Genes, BRCA2 / Germ-Line Mutation / Humans / Metastasis / Middle Aged / Mutation / Patient Reported Outcome Measures / Patients / Phthalazines - adverse effects / Phthalazines - therapeutic use / Poly(ADP-ribose) Polymerase Inhibitors - adverse effects / Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use / Quality of Life / Response rates / Ribose / Survival / Survival Analysis / Tumors / Vinorelbine

2018

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Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

2018

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Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

2018

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Journal Article

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

Rugo, Hope S,

Mina, Lida A,

Roché, Henri,

Tudor, Iulia C,

Im, Young-Hyuck,

Fehrenbacher, Louis,

Blum, Joanne L,

Eiermann, Wolfgang,

Lee, Kyung-Hun,

Yerushalmi, Rinat,

Gonçalves, Anthony,

Martin, Miguel,

Litton, Jennifer K,

Hurvitz, Sara A,

Ettl, Johannes,

Quek, Ruben G.W,

Markova, Denka,

Hannah, Alison L

2018

Overview

Among patients with breast cancer and germline mutations in the BRCA DNA repair pathway genes, the poly(adenosine diphosphate–ribose) inhibitor talazoparib provided a significant benefit over standard chemotherapy with respect to progression-free survival.

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Publisher

Massachusetts Medical Society

Subject

Adenosine

/ Adult

/ Aged

/ Aged, 80 and over

/ Antineoplastic Agents - adverse effects

/ Antineoplastic Agents - therapeutic use

/ Antitumor activity