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Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke
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Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke
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Journal Article
Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke
2021
Overview
Ischemic stroke can induce neurogenesis. However, most stroke-generated newborn neurons cannot survive. It has been shown that MR-409, a potent synthetic agonistic analog of growth hormone–releasing hormone (GHRH), can protect against some life-threatening pathological conditions by promoting cell proliferation and survival. The present study shows that long-term treatment with MR-409 (5 or 10 μg/mouse/d) by subcutaneous (s.c.) injection significantly reduces the mortality, ischemic insult, and hippocampal atrophy, and improves neurological functional recovery in mice operated on for transient middle cerebral artery occlusion (tMCAO). Besides, MR-409 can stimulate endogenous neurogenesis and improve the tMCAO-induced loss of neuroplasticity. MR-409 also enhances the proliferation and inhibits apoptosis of neural stem cells treated with oxygen and glucose deprivation–reperfusion. The neuroprotective effects of MR-409 are closely related to the activation of AKT/CREB and BDNF/TrkB pathways. In conclusion, the present study demonstrates that GHRH agonist MR-409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice.
Publisher
National Academy of Sciences
Subject
/ Animals
/ Atrophy
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - metabolism
/ Cell Proliferation - drug effects
/ Cyclic AMP response element-binding protein
/ Cyclic AMP Response Element-Binding Protein - metabolism
/ Growth hormone-releasing hormone
/ Growth Hormone-Releasing Hormone - agonists
/ Growth Hormone-Releasing Hormone - genetics
/ Growth Hormone-Releasing Hormone - metabolism
/ Infarction, Middle Cerebral Artery - metabolism
/ Ischemia
/ Ischemic Stroke - metabolism
/ Male
/ Membrane Glycoproteins - metabolism
/ Mice
/ Nerve Regeneration - drug effects
/ Neural Stem Cells - metabolism
/ Protein-Tyrosine Kinases - metabolism
/ Recovery
/ Recovery of Function - drug effects
/ Stroke
